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Brefeldin a

Brefeldin a

(Science: chemical) a macrocyclic lactone synthesised from palmitic acid by several fungi.

It was initially described as an antiviral antibiotic, but it was later found to inhibit protein secretion at an early stage, probably blocking secretion in a pre Golgi compartment. Its exact site of action is still a matter of debate, one suggestion being that it inhibits the binding of regulatory coat proteins to organellar membranes.

nevertheless, it has proved a valuable tool for studying membrane traffic and the control of organelle structure.

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cell cultur medium

... STREP-PENICYLINE. I prepar the complete medium to thaw PBMCs frozen in nitrogen liquid and to do three hours of cell cultur whit PMA + IONOMICIN + BREFELDIN A. thanks for helps

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by tregis6
Wed Jul 30, 2008 4:53 pm
Forum: Cell Biology
Topic: cell cultur medium
Replies: 0
Views: 1115


... like nocodazole and colcemid , that bind free tubulin in a cell and prevent them from adding onto microtubules. I also know of a drug called Brefeldin that interferes with anterograde transport from the endoplasmic reticulum to the golgi apparatus but I'm not sure of the mechanism (I would ...

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by Jammerz
Sun Nov 11, 2007 8:36 am
Forum: Genetics
Topic: Colchicine
Replies: 8
Views: 12738

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