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Bradykinin

Bradykinin

(Science: protein) vasoactive nonapeptide (RPPGFSPFR) formed by action of proteases on kininogens. Very similar to kallidin (which has the same sequence but with an additional N terminal lysine). Bradykinin is a very potent vasodilator and increases permeability of post capillary venules, it acts on endothelial cells to activate phospholipase A2. It is also spasmogenic for some smooth muscle and will cause pain.


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Ace Inhibitors

how does ace inhibitors increase nitric oxide? I looked at the MOA and ACE-I drugs block bradykinin which makes NO and tpa. I know tpa goes down but NO is suppose to go up after taking an ace inhibitor?? How can NO increase? Help please?

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by zmike
Wed Oct 17, 2012 5:02 am
 
Forum: Human Biology
Topic: Ace Inhibitors
Replies: 0
Views: 943

Connection between opioid receptors and fatty acid receptors

... Some outtakes: Blood vessels were regulated by some of these receptors. Bradykinin widens blood vessels lowering blood pressure and angiotensin has opposite effects to bradykinin. Thrombin and platelet activating factor ...

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by mhein
Tue Jul 10, 2012 2:00 pm
 
Forum: Evolution
Topic: Connection between opioid receptors and fatty acid receptors
Replies: 4
Views: 8230

Contact Dermatitis ( allergic)

... nickel but can be rubber and all sorts of things). The complex attaches to a mast cell IgE receptor which releases mediators such as histamin and bradykinin upon binding IgE loaded with antigen to its IgE receptor. This releases causes the itching etc and that's what's meant be an 'overreaction'. ...

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by weesper
Tue Aug 15, 2006 9:52 am
 
Forum: Human Biology
Topic: Contact Dermatitis ( allergic)
Replies: 3
Views: 2107

G-proteins

... PIP2) generating the second messengers, diacylglycerol (DAG) and inositoltrisphosphate (IP3). This class of receptors includes the angiotensin, bradykinin and vasopressin receptors. 3. A novel class of GPCRs are the photoreceptors. This class is coupled to a G-protein termed transducin that ...

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by blindcat35
Sat Feb 04, 2006 6:31 am
 
Forum: Cell Biology
Topic: G-proteins
Replies: 4
Views: 6802


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