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Binding constant



A mathematical constant that describes the bonding affinity between two molecules at equilibrium.


It is the measure of the affinity of an enzyme for its substrate. An example is the measure of the strength of binding in the hapten-antibody interaction.

Symbol: Ka


Compare: dissociation constant

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Competitive receptor-ligand Binding

... dose-response curve will be shifted to the right in the presence of a constant concentration of an antagonist that binds to the same receptor" ... The only conclusion I could think of is that there could be another binding site (one of lower affinity) which would increase the maximal response, ...

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by someguy456345
Thu Feb 24, 2011 7:48 pm
Forum: Cell Biology
Topic: Competitive receptor-ligand Binding
Replies: 0
Views: 2150


... produces which of the following: A Fab fragment Monovalent antigen binding fragments Isolated heavy chains F(ab')2 Isolated light chains I think ... change of the Ag/Ab interaction Always equal to avidity The association constant of the Ag/Ab equilibrium 4) Select the ONE answer that is CORRECT. ...

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by pinkypig
Thu Feb 05, 2009 5:12 pm
Forum: General Discussion
Replies: 0
Views: 3477

Re: How do you calculate dissociation constant?

... your bound protein concentration is also 10 mM (the bound protein and bound ATP concentrations have to be equal assuming a 1:1 stoichiometry of binding) leaving you with 20-10 or 10 mM of free protein that is not complexed with any ATP, [P], at equilbrium. Since you used 10 mM of your total ...

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by blcr11
Mon Sep 29, 2008 5:33 pm
Forum: Molecular Biology
Topic: How do you calculate dissociation constant?
Replies: 11
Views: 16674

Multiple choice questions

... factors binds to: a. A intact DNA double helix, and promotes the binding of RNA Polymerase b. Simple stranded DNA c. Special seats where DNA ... b. The changes in [S] are insignificant and [S] can be looked on as a constant c. The changes in [Km] are insignificant and [Km] can be looked ...

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by Luna
Thu Apr 03, 2008 9:32 am
Forum: Molecular Biology
Topic: Multiple choice questions
Replies: 2
Views: 5895

HIstory ...

... [Adolf Hitler, Mein Kampf, Vol. 1, Chapter 5] Only in the steady and constant application of force lies the very first prerequisite for success. ... or negation until emotional divination or knowledge assumes the binding force of apodictic faith. This, above all, is the fighting factor ...

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by E8-not42
Sat Nov 17, 2007 5:55 pm
Forum: Evolution
Topic: God vs Evolution
Replies: 274
Views: 257588
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