Bay region

Bay region

(Science: chemistry) An indentation of three fused benzene rings. A common bay region is the site on benzo(a)pyrene, an indirect carcinogen that is metabolically activated by the p-450 system at the 7,8-double bond, leading to a 7,8-oxide, which is rapidly converted to a 7,8-dihydrodiol and later epoxidated near the bay region at the 9,10-double bond.

The resulting product, a diol-epoxide is a poor substrate for epoxide hydratase and is released from the mitochondria into the cell as a highly reactive electrophil, becoming an ultimate carcinogen, as it reacts with negative charges in dna.

Retrieved from "http://www.biology-online.org/bodict/index.php?title=Bay_region&oldid=58581"
First | Previous (Bay-antler) | Next (Bay sore) | Last
Please contribute to this project, if you have more information about this term feel free to edit this page.