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Basal lamina



(histology) A layer of extracellular matrix found on the basal surface of epithelial cells, and which is secreted by the epithelial cells.

(embryology) The ventral plate of the embryonic neural tube that gives rise to somatic and visceral motor neurons.


In histology, basal lamina is composed of electron-dense layer called lamina densa (composed of type IV collagen) and electron-lucid layers called lamina lucida (made up of laminin, integrins, entactins, and dystroglycans) together make up the basal lamina.

The term "basal lamina" is usually used with electron microscopy, while the term "basement membrane" is usually used with light microscopy. That is because basal lamina is readily visible as distinct structure with the electron microscope, and not with a light microscope. In strict sense, basal lamina is different from basement membrane based on their components. The basal lamina is composed of lamina densa and lamina lucida whereas the basement membrane is composed of lamina densa and lamina reticularis; hence, the basement membrane includes only a portion of basal lamina, and including a layer not found in basal lamina.

Derived terms:

Synonym: ventral plate of neural tube (embryology).
Compare: basement membrane.

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Extracellular matrix

The epithelial cells is the outer most surface basal lamina also known as the basement membrane (extracellular matrix) layer Support tissue is the next ...

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by merge
Sat Mar 08, 2008 12:43 pm
Forum: Cell Biology
Topic: Extracellular matrix
Replies: 3
Views: 3711

nuclear lamina

lumen: space in a tube(like the inside of a pipe) lamina: can refer to more than one structure. see here: http://en.wikipedia.org/wiki/Lamina ... filaments that make up the nuclear lamina laminin: protein that makes up the basal lamina of epithelial tissues.

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by MrMistery
Fri Nov 23, 2007 1:00 pm
Forum: General Discussion
Topic: nuclear lamina
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