Barbiturates

... is the mechanism for pharmacodynamic drug tolerance (for example opioids or benzodiazepins). Also there is pharmacokinetic drug tolerance (for barbiturates) wich has nothing to do with receptors, but with the drug increasing its own metabolization by the liver.

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... phenytoin, procainamide, quinidine, salicylate, streptomycin, theophylline, tobramycin, valproic acid, vancomycin, ethanol, amphetamines, barbiturates, benzodiazepine, buprenorphine, cannabinoids, cocaine, cocaine metabolites, fentanyl, lysergic acid diethylamide, methadone, nicotine, ...

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... of that in the plasma. Interactions Drugs which depress the central nervous system can be potentiated by pimozide. These drugs include alcohol, barbiturates, anesthetics, antihistamines and benzodiazepines. The use of pimozide together with any of these should be minimized. QT wave lengthening ...

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