Autoimmunity

... a big chance that there's actually not much disagreement between us, just different attitudes/perspective to the same problem, for instance autoimmunity for me is also a sign of weakened immunity, but not in the strict sense - of course I can be wrong in many/even all points, but being authoritative ...

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... considerable (or even fatal) auto-immune effects, but obviously that is not what happens in reality. The downside of this is the increased risk of autoimmunity, because these "loose" TCRs may recognize self antigens in a similar manner as they recognize (mutated) viral antigens. Right, ...

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... considerable (or even fatal) auto-immune effects, but obviously that is not what happens in reality. The downside of this is the increased risk of autoimmunity, because these "loose" TCRs may recognize self antigens in a similar manner as they recognize (mutated) viral antigens. Right, ...

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... 2011"), where they handled the properties of T cells responding to the T cell receptor signals. Although the article focused mainly on autoimmunity, they said that many clonal TCRs can recognize several epitopes with varying affinities - with varying outcomes. So even if a virus could ...

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There are some articles that you could search thru on PubMed. Just type in CTLA-4 and autoimmunity Review. http://www.ncbi.nlm.nih.gov/sites/entrez

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