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Autocrine signaling



A form of cell signaling in which a cell secretes an autocrine agent (e.g. hormone or chemical messenger) that binds to autocrine receptors on the same cell, leading to changes in the cell.


An example of an autocrine agent is the cytokine interleukin-1 in monocytes. When this is produced in response to external stimuli, it can bind to cell-surface receptors on the same cell that produced it.

Word origin: "autos" = self.

Compare: paracrine signaling.

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Hard Advanced Cell Biology Question

... that, at 21C, proliferate and differentiate into cardiomyoctes. The signaling system leading to differentiation seems to involve the PI3K-Akt/PKB ... the graduate student discovered that his cells were producing an autocrine factor that was causing the cells to proliferate without differentiating ...

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by superscience
Mon Dec 03, 2007 11:41 pm
Forum: Cell Biology
Topic: Hard Advanced Cell Biology Question
Replies: 0
Views: 3130

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