Dictionary » A » Autoantigen



noun, plural: autoantigens

An endogenous antigen that is recognized as nonself by the immune system, which should be considered otherwise under normal conditions.


Production of autoantigens occurs under normal conditions, especially when a cell becomes neoplastic that it has to be recognized and acted upon by the immune system. However, when the immune system continues to fail to recognize own constituent parts as self it can lead to an autoimmune disease.

Word origin: from Greek autós self + antigen.

Also called: self-antigen

See also: autoimmunity.

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Re: Gluten-free and Vaccines

... Hill, Nature Med. 6, 337(2000). 10. W. Dieterich et al., Nature Med. 3, 797 (1997). 11. The extracellular tissue transglutaminase is the primary autoantigen in Celiac Sprue (10). 12. L. M. Sollid et al., J. Exp. Med. 169, 345 (1989). 13. The class II HLA DQ2 molecule is expressed in 90% of Celiac ...

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by tmerezko
Tue Jun 22, 2010 6:08 pm
Forum: General Discussion
Topic: Gluten-free and Vaccines
Replies: 7
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