An agglutinating autoantibody.

Anti-pr cold autoagglutinin, a cold autoagglutinin specific for the pr (protease-sensitive) antigen of erythrocytes.

cold autoagglutinin, a heterogeneous group of autoantibodies that react at temperatures below 37�C, often most actively at 4�C; most are the igm class of immunoglobulins with affinity for the Ii system of erythrocyte antigens, but some are anti-pr cold autoagglutinin's; cold autoagglutinin's may be associated with infection (e.g., primary atypical pneumonia, infectious mononucleosis and other virus infections, certain protozoan infections) and in such instances usually are not active in vivo.

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