Atropine

Atropine

(Science: drug) a toxic alkaloid extracted from belladonna and other members of thenightshade family, it is typically used to dilate the eye and to stopmuscular spasms.

pharmacologic action: Parasympatholytic. Competitive blockade of acetylcholine at muscarinic receptors. Increases sinus node automaticity and av conduction.

Uses: treat bradycardia, asystole, and av block

Dose: 0.5 - 1.0 mg for bradycardia every 3 - 5 min to a total dose of 0.04 mg/kg. Doses smaller than 0.5 mg can cause a paradoxical bradycardia due to sympathomimetic effects Typically 3 mg is adequate to completely block vagal effects atropine is well absorbed via endotracheal route - administer 1-2 mg diluted in 10 ml sterile water or normal saline.

potential complications: 1. Tachyarrhythmias 2. Exacerbation of myocardial ischemia 3. Low dose may cause paradoxical bradycardia 4. Dry mouth, urinary retention, flushed and hot skin 5. Crosses blood-brain barrier which can cause delirium

Note: The denervated heart will not respond to atropine.


Please contribute to this project, if you have more information about this term feel free to edit this page



This page was last modified on 3 October 2005, at 21:16. This page has been accessed 6,139 times. 
What links here | Related changes | Permanent link