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Atropine

Atropine

(Science: drug) a toxic alkaloid extracted from belladonna and other members of thenightshade family, it is typically used to dilate the eye and to stopmuscular spasms.

pharmacologic action: Parasympatholytic. Competitive blockade of acetylcholine at muscarinic receptors. Increases sinus node automaticity and av conduction.

Uses: treat bradycardia, asystole, and av block

Dose: 0.5 - 1.0 mg for bradycardia every 3 - 5 min to a total dose of 0.04 mg/kg. Doses smaller than 0.5 mg can cause a paradoxical bradycardia due to sympathomimetic effects Typically 3 mg is adequate to completely block vagal effects atropine is well absorbed via endotracheal route - administer 1-2 mg diluted in 10 ml sterile water or normal saline.

potential complications: 1. Tachyarrhythmias 2. Exacerbation of myocardial ischemia 3. Low dose may cause paradoxical bradycardia 4. Dry mouth, urinary retention, flushed and hot skin 5. Crosses blood-brain barrier which can cause delirium

Note: The denervated heart will not respond to atropine.


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Dilution

Take 5 small glass test tubes (1-5) and put 1200 μl of distilled water in each. Now add 300 μl of 10 μM atropine to Tube 1, mix well and transfer 300 μl to Tube 2. Mix well and transfer 300 μl to Tube 3. Repeat up to Tube 5. Calculate the atropine concentration in each tube. ...

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by carbonp
Fri Oct 16, 2009 5:37 pm
 
Forum: Molecular Biology
Topic: Dilution
Replies: 1
Views: 742

Antimuscarinic drugs

No pharmacology forum perse, but they are kind of physiological questions. A long time ago in a land far away, Scopalamine/Atropine were used to prep a person for anaethesia to prevent secretions buildup in bronchial passages. One use in particular, was obstetric delivery. Q1. Would ...

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by raneynickel
Thu Sep 24, 2009 6:50 am
 
Forum: Physiology
Topic: Antimuscarinic drugs
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The Fiber Disease

... arecaidine, guvacine, pilocarpine, cytisine, nicotine, sparteine, pelletierine. Pyrrolidine group: hygrine, cuscohygrine, nicotine Tropane group: atropine, cocaine, ecgonine, scopolamine Quinoline group: quinine, quinidine, dihydroquinine, dihydroquinidine, strychnine, brucine, veratrine, cevadine ...

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by Skytroll
Wed Jul 12, 2006 6:01 pm
 
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Topic: The Fiber Disease
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The Fiber Disease

... sometimes vomiting) are part of a generalized complaint of not feeling well. Miosis, pain, dim vision, and nausea can be relieved by topical homatropine or atropine in the eye. Nose: Rhinorrhea may be the first indication of nerve agent vapor exposure. Its severity is dose dependent. Airways: ...

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by London
Sun Apr 16, 2006 3:45 pm
 
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