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Arrestins

a family of inhibitory proteins that bind to tyrosine phosphorylated receptors, thereby blocking their interaction with g-proteins and effectively terminating the signalling. Arrestin (s antigen, 48 kd, from retinal rods) competes with transducin for light activated rhodopsin, thus inhibiting the response to light (adaptation). Immune responses to arrestin lead to autoimmune uveitis. Similarly, _ arrestin binds to phosphorylated _ adrenergic receptors, inhibiting their ability to activate the g protein Gs