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Arginine

Arginine is an amino acid (formula C6H14N4O2, molecular weight: 174.20). The ā€œLā€ form is one of the 20 most common natural amino acids. In mammals, arginine is classified as a semi-essential or conditionally essential or non-essential amino acid, depending on the developmental stage and health status of the individual. Infants are unable to effectively synthesize arginine, making it nutritionally essential for infants. Adults, however, are able to synthesize arginine in the urea cycle. Arginie is produced in the human body by the digestion, or hydrolysis of proteins. Arginine can also be produced synthetically. Because it is produced in the body, it is referred to as "nonessential," meaning that no food or supplements are necessary for humans to ingest.

Research has shown the use of l-arginine has many benefits including: improves immune response to bacteria, viruses, and tumor cells. promotes wound healing by repairing tissues. plays a crucial role in the regeneration of liver. responsible for release of growth hormones promotes muscle growth improves cardiovascular functioning

L-arginine is a precursor of Nitric Oxide (NO), urea, ornithine and agmatine and is necessary for the synthesis of creatine. A recent Johns Hopkins study testing the addition of L-arginine to standard postinfarction treatment has implicated L-arginine supplementation with an increased risk of death in patients recovering from heart attack. Data derived from NIST (National Institute of Standards Technology). Much more physical and chemical property data is available from the NIST/TRC Table Database


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Re: Homework help!

... C) UAC UGA GCG AAU GCA AUU D) I am assuming we are using (AUG ACA CGC UUA CGU UAA): 1. AUG = Methionine (start codon) 2. ACA = Threonine 3. CGC = Arginine 4. UUA = Leucine 5. CGU = Arginine 6. UAA = Stop [Not entirely sure about the last, but the sequencing seems to work out correctly]

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by Mech
Thu Mar 19, 2009 12:25 pm
 
Forum: Genetics
Topic: Homework help!
Replies: 5
Views: 575

Re: Proteolysis of protease

... - based on amino acid sequence, charge, size, etc. For example trypsin cleaves peptide chains at the carboxyl side of the amino acids lysine and arginine, except when either is followed by proline. The "lipase" you describe may or may not fit in to the specifity for the "protease" ...

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by JorgeLobo
Sun Feb 22, 2009 1:22 pm
 
Forum: Molecular Biology
Topic: Proteolysis of protease
Replies: 5
Views: 890

Re: is it possible to knockdown a gene in a living adult now

... says that "Qi Long Lu, a pathologist at Carolinas Medical Center in Charlotte, North Carolina, has added a peptide rich in the amino acid arginine to the morpholino antisense." Sorry, Science, you got that one wrong. That peptide was developed and added by my wife, Hong Moulton of ...

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by jonmoulton
Fri Dec 05, 2008 8:41 pm
 
Forum: Genetics
Topic: is it possible to knockdown a gene in a living adult now
Replies: 10
Views: 1509

Re: is it possible to knockdown a gene in a living adult now

Yes. Following are references related to conjugation of Morpholino oligos with arginine-rich peptides. Zhang B, Dong H, Stein DA, Shi PY. Co-selection of West Nile virus nucleotides that confer resistance to an antisense oligomer while maintaining long-distance ...

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by jonmoulton
Fri Nov 07, 2008 3:44 pm
 
Forum: Genetics
Topic: is it possible to knockdown a gene in a living adult now
Replies: 10
Views: 1509

Re: how to knock out a gene?

... morpholino oligomers. Antisense Nucleic Acid Drug Dev. 2003 Feb;13(1):31-43. Variations on the peptide were tried, leading to development of arginine-rich peptides incorporating non-natural amino acids that delivered Morpholinos much more efficiently than the Tat peptide: Wu RP, Youngblood ...

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by jonmoulton
Fri Oct 17, 2008 4:38 pm
 
Forum: Genetics
Topic: how to knock out a gene?
Replies: 4
Views: 1307
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