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Apurinic dna

Apurinic dna

(Science: molecular biology) a dna molecule that has lost adenine and guanine, its purine bases.

apurinic dna can be produced by treating the dna with acid.


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PCR of degraded DNA

... only for small damage like " including those that block PCR (e.g. apurinic/apyrimidinic sites, thymine dimers, nicks and gaps) and those that ... he was talking about a little more severe damage, like broken down DNA And that won't this mix fix ;) And that also explains your fun fact ;)

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by JackBean
Thu Nov 19, 2009 4:32 am
 
Forum: Genetics
Topic: PCR of degraded DNA
Replies: 5
Views: 4265

DMSO in PCR

... addition of DMSO is used in PCR to prevent 2nd stucture formation of DNA but it increases DNA mutation rate (which I conclude will give wrong ... destabilizes DNA by disturbing purine-deoxyribose bond, yielding apurinic acid. Is it true? Thanks. Victor Apriel

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by victor
Mon Jul 21, 2008 5:08 am
 
Forum: Molecular Biology
Topic: DMSO in PCR
Replies: 1
Views: 7692


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