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Apoptosis

Apoptosis

(Science: cell biology) Programmed cell death as signalled by the nuclei in normally functioning human and animal cells when age or state of cell health and condition dictates.

An active process requiring metabolic activity by the dying cell, often characterised by cleavage of the dna into fragments that give a so called laddering pattern on gels.

cells that die by apoptosis do not usually elicit the inflammatory responses that are associated with necrosis, though the reasons are not clear.

cancerous cells, however, are unable to experience the normal cell transduction or apoptosis-driven natural cell death process.

See: ced mutant, bcl.


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... agents have various ways of action, but they all aim to impair mitosis and thus kill fast dividing cells as well -- or force them to undergo apoptosis. So, as peculiar as it may sound, in radiotherapy cancer is fought with its own weapons: mutations.

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by alieen
Sat Dec 20, 2014 5:10 am
 
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by PeterDow
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... to the strand. but it gets shorter as the replication cycle. as cells age, the telomeres get shorter! shortest telomere or lack of it, signals apoptosis. Cancer cells avoids apoptosis, by synthesis of more and more telomeres which synthesis the ends of chromosomes for the cancer cells...

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by balamurugan3
Sat Aug 10, 2013 3:52 am
 
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Sat Mar 30, 2013 3:03 pm
 
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