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Antibody diversity

Antibody diversity

The phenomenon of immense variability characteristic of antibodies, which enables the immune system to react specifically against the essentially unlimited kinds of antigens it encounters. Antibody diversity is accounted for by three main theories: 1) the germ line theory, which holds that each antibody-producing cell has genes coding for all possible antibody specificities, but expresses only the one stimulated by antigen; 2) the somatic mutation theory, which holds that antibody-producing cells contain only a few genes, which produce antibody diversity by mutation; and 3) the gene rearrangement theory, which holds that antibody diversity is generated by the rearrangement of variable region gene segments during the differentiation of the antibody-producing cells.

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Re: Theories - Origin of Life

... roles, such as gene expression, gene regulation, generation of genetic (antibody, antigenic, and other) diversity. Pseudogenes are involved in gene conversion or recombination with functional genes……” ...

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by scottie
Sun Dec 18, 2011 3:40 pm
Forum: Evolution
Topic: Theories - Origin of Life
Replies: 563
Views: 1128010

Existing antibodies that will counter antigens yet to contac

The explanation is diversity. The B cells that produce antibodies have a vast diversity of genes that encode for the variable part of the antibody molecule. Thus they are able to produce thousands of differents types of antibodies. These ...

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by biohazard
Fri Dec 11, 2009 6:58 am
Forum: Genetics
Topic: Existing antibodies that will counter antigens yet to contac
Replies: 4
Views: 2715

The Fiber Disease

... useful marker for viral infection. HIV-1 RNA appears in plasma prior to antibody response, providing a very sensitive method for early detection ... of screening assays for this virus is its high degree of genetic diversity, which includes two major groups M and O. and several subtypes ...

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by London
Thu Nov 23, 2006 4:15 am
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 6245151

B and T Cells

... recognizing the same antigens are from the same clone. There is a great diversity of lymphocytes B which makes our body able to recognize an almost ... permit a second more effective response to an antigen contact. The antibody is not capable of directly destroying the invasive organisms but ...

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by BioCell
Thu Oct 12, 2006 5:34 pm
Forum: Human Biology
Topic: B and T Cells
Replies: 7
Views: 5514

The Molecular Biology of the Cell, 4th Edition, online FREE!

... Cell 1. Cells and Genomes The Universal Features of Cells on Earth The Diversity of Genomes and the Tree of Life Genetic Information in Eucaryotes ... Basis of Adaptive Immunity B Cells and Antibodies The Generation of Antibody Diversity T Cells and MHC Proteins Helper T Cells and Lymphocyte ...

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by JacobK
Thu Sep 22, 2005 12:33 pm
Forum: PDF & Doc Files
Topic: The Molecular Biology of the Cell, 4th Edition, online FREE!
Replies: 5
Views: 210989

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