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Antibody affinity

Antibody affinity

a measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of avidity, which refers to the strength of the antigen-antibody bond after formation of reversible complexes.

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antibody/antigen pair with a Kd of 10^-6 M or higher

Hi, I'm looking for an antibody/antigen pair with a Kd of 10^-6 M or higher, (that is, weaker affinity than that) I was trying to use the protein data bank and could find binding affinity under advanced ...

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by TheWalkingGlitch
Sat Nov 19, 2011 8:48 pm
Forum: Bioinformatics
Topic: antibody/antigen pair with a Kd of 10^-6 M or higher
Replies: 2
Views: 2267

Killer Cells vs. Cytotoxic Cells

... (unlike T and B cells, who undergo clonal expansion and increased antibody affinity etc.). Thus, NK cells are considered to be a part of the innate immune system: they ...

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by biohazard
Mon May 02, 2011 8:23 am
Forum: Cell Biology
Topic: Killer Cells vs. Cytotoxic Cells
Replies: 9
Views: 38908

Re: Gluten-free and Vaccines

... segments of both pertactin and the phosphatase are likely to be high-affinity tTGase substrates. To test this hypothesis, we synthesized the corresponding ... Analogous to gliadin in Celiac Sprue, pertactin elicits a vigorous antibody response because it reacts with tTGase on the extracellular ...

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by tmerezko
Tue Jun 22, 2010 6:08 pm
Forum: General Discussion
Topic: Gluten-free and Vaccines
Replies: 7
Views: 20105

Re: Cytokine - Receptor concepts

... Otherwise, T lymphocites can be usefull in B cell activation and antibody production, here it’s named T helper cell, and this is known as ... late events in helper T cell dependent antibody responses, including affinity maturation and the generation of memory B cells, occur in the germinal ...

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by marla
Tue Jun 01, 2010 9:08 pm
Forum: Cell Biology
Topic: Cytokine - Receptor concepts
Replies: 7
Views: 16939

Existing antibodies that will counter antigens yet to contac

... have a vast diversity of genes that encode for the variable part of the antibody molecule. Thus they are able to produce thousands of differents ... antibody for any antigen out there, some of which have a very high affinity, some a bit lower. If these B cells then recognize the antigen with ...

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by biohazard
Fri Dec 11, 2009 6:58 am
Forum: Genetics
Topic: Existing antibodies that will counter antigens yet to contac
Replies: 4
Views: 2718
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