Amrinone

Amrinone

(Science: chemical) a positive inotropic cardiotonic agent with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell. Its therapeutic use in congestive heart or left ventricular failure is associated with significant increases in the cardiac index, reductions in pulmonary capillary wedge pressure and systemic vascular resistance, and little or no change in mean arterial pressure. One of its more serious side effects is thrombocytopenia in some patients.

Pharmacological action: calcium channel blockers, cardiotonic agent, phosphodiesterase inhibitors, vasodilator agents.

chemical name: (3,4'-Bipyridin)-6(1H)-one, 5-amino-

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