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Allosteric

Definition

adjective

Pertaining to or involving a change in the shape and activity of a protein, usually an enzyme, when it binds with a molecule on a region other than its active site.


Supplement

A protein may both have an active site that binds with the substrate and an allosteric site that binds with a different molecule (called an effector). For instance, a partially deoxygenated hemoglobin binds allosterically with 2,3-Bisphosphoglycerate that upregulates the release of the remaining oxygen molecules bound to the hemoglobin, thus, enhancing the ability of the RBC to release oxygen near tissues that need it most.


Word origin: from the Greek allos, "other," and stereos, "space,"
Related forms: allostery (noun), allosterically (adverb)
See also: enzyme, active site, substrate, effector.


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Enzymes

... of rate of one enzyme, then you're interested in things such as posttranslational regulation (phosphorylation). As jonmoulton mentioned, allosteric regulators are important.

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by JackBean
Tue Aug 21, 2012 9:15 pm
 
Forum: Molecular Biology
Topic: Enzymes
Replies: 23
Views: 14750

Re: Enzymes

... amino acid change can alter or eliminate activity. Temperature and pH affect rate. Many enzymes are controllable by other enzymes -- look at allosteric regulation: http://en.wikipedia.org/wiki/Allosteric

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by jonmoulton
Mon Aug 20, 2012 10:37 pm
 
Forum: Molecular Biology
Topic: Enzymes
Replies: 23
Views: 14750

Fumarase inhibitors anyone?

Hi, Anyone know of any Fumarase inhibitors, anyone? Competitive or allosteric, but preferably competetive. Any reply would be greatly appreciated. Thanks.

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by billyfisher100
Wed Feb 15, 2012 6:34 pm
 
Forum: Molecular Biology
Topic: Fumarase inhibitors anyone?
Replies: 2
Views: 1094

Energy, enzymes & metabolism Questions.

... "What is the difference between the mechanism of action of competitive and non-competitive enzyme inhibitors?", "How do allosteric enzymes control feedback regulation in metabolic pathways?" or "What factors influence enzyme activity?"? If you just tried ...

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by JackBean
Fri Sep 30, 2011 1:35 pm
 
Forum: Molecular Biology
Topic: Energy, enzymes & metabolism Questions.
Replies: 4
Views: 10394

Energy, enzymes & metabolism Questions.

... the mechanism of action of competitive and non-competitive enzyme inhibitors? What is the relationship between enzymes and coenzymes? How do allosteric enzymes control feedback regulation in metabolic pathways? What factors influence enzyme activity?

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by arasfromexile
Fri Sep 30, 2011 10:19 am
 
Forum: Molecular Biology
Topic: Energy, enzymes & metabolism Questions.
Replies: 4
Views: 10394
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