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Adducted thumbs with mental reatardation

a syndrome with the following characteristic features: (1) neurologically:mental retardation and aphasia (lack of speech); (2) limbs: adducted (clasped) thumbs, absent extensor pollicis longus and/or brevis muscles to the thumb, shuffling gait, and leg spasticity; (3) growth: small body size; (4) skeleton: lumbar lordosis (sway back). The syndrome is inherited as an x-linked trait and so affects mainly boys. Alternative names include MASA syndrome ( MASA stands for mental retardation, aphasia, shuffling gait, and adducted thumbs), clasped thumb and mental retardation, congenital clasped thumb with mental retardation, and the Gareis-Mason syndrome.