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Active principle

Active principle

a constituent of a drug, usually an alkaloid or glycoside, upon the presence of which the characteristic therapeutic action of the substance largely depends.


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EC50 depending on cell number?

... to cell layers growing over each other or senescence etc. Just from the principle. Say I have compound X that I use in a 96-well format and in each ... I cannot really explain why it is wrong. For example: - When I have an active compound at e.g. 10 uM this will be the needed concentration I will ...

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by qforthemass
Tue Aug 14, 2012 9:40 pm
 
Forum: Cell Biology
Topic: EC50 depending on cell number?
Replies: 1
Views: 1917

Molecular gene (genome) concept scientifically untenable

... chemistry.” [3]. It has been known since about 1913 that the individual active units of heredity - the genes - are strung together in one-dimensional ... be specific to the structure. But in reality, the genome defies this principle in a variety of ways. a) Changes in the phenotype during ontogenetic ...

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by PAWahid
Wed May 02, 2012 4:54 am
 
Forum: Molecular Biology
Topic: Molecular gene (genome) concept scientifically untenable
Replies: 12
Views: 14511

Re: Theories - Origin of Life

... vision of evolutionary engineering that postulates a more regular principle-based process of change than the gradual random walk of 19th and ... has amply confirmed McClintock�s discovery that living organisms actively reorganize their genomes (5). It has also supported her view that ...

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by scottie
Mon May 23, 2011 8:28 pm
 
Forum: Evolution
Topic: Theories - Origin of Life
Replies: 549
Views: 600489

Re: Enzymes and activation energy.

... Wikipedia on Enzymes: The mechanism of enzyme catalysis is similar in principle to other types of chemical catalysis. By providing an alternative ... shape, brings the reactants (or substrates) closer together into its active site, This is the alternative route, and: allowing the chemical bonds ...

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by kolean
Wed Jul 08, 2009 5:04 pm
 
Forum: Molecular Biology
Topic: Enzymes and activation energy.
Replies: 4
Views: 22831

Re: A biochemical question

... drive the forward reaction a bit (by good old Le Chatelier's principle), generating more product. Fairly quickly, though, the rate of ... enzyme is still “catalyzing” is just to say that the enzyme is still active. At steady state, the enzyme is “catalyzing” the production and consumption ...

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by blcr11
Wed Dec 24, 2008 2:43 pm
 
Forum: Molecular Biology
Topic: A biochemical question
Replies: 8
Views: 5519
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