Acetylcholine

... the continuous firing of a Postsynaptic Neuron From what I've read, I think one of the reasons is if Cholinesterase wasn't active to destroy the Acetylcholine, and I'm not sure of the other, I'm probably wrong on the first one as well but I'm getting so confused reading the same stuff over and ...

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... much of a difference. The fact this(i think), there is already enough cholinesterase in the synaptic cleft to quickly degrade any molecules of acetylcholine that are not attached to the receptor. In an extreme cases, the cholinesterase would simply block the nerve impulse, having similar effects ...

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Hello, I would like to know the association rate constant of Ach to mAchR but i can't find this information !! And in general how to find this kind of informations (scientific papers are sometimes for me not really understanding)? Thnaks a lot in advance. Nicolas.

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Hello, I'm looking for a kinetic model for modeling the AchE with or without antagonists (Tacrine, Galantamine and so on). I mean i would like differential equations so see the production of choline during time. Thanks a lot. Nicolas.

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Hello, I would like to know the basal concentration of AchE in the cleft because would like to modeling this enzyme using a kinetic scheme. Currently my model is works only for some concentrations!! Thanks in advance. Nicolas Ambert.

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