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Accumulation

Accumulation

The action or process of accumulating, state of being or having accumulated, a collecting together.

(Science: pharmacology) Repeated exposures to a chemical or drug may result in the progressive increase of its concentration in an organism, organ or tissue. Illness or other effects may increase with successive doses.

factors involved in accumulation include selective binding of the drug to tissue molecules, concentration of fat soluble drugs in body fat, absent or slow metabolism of the drug, and slow excretion of the drug.

accumulation is a mass balance effect where input exceeds output.


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... and the Origin of Menopause. PLoS Comput Biol 9(6): e1003092. doi:10.1371/journal.pcbi.1003092 . The idea is that menopause is the result of an accumulation of detrimental mutations, which become fixed because there is little selection AGAINST them; due to the mating preference against older ...

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by badgertoes
Sat Dec 28, 2013 9:01 am
 
Forum: Evolution
Topic: Gender divison in two opposites is greatest mistake of manki
Replies: 24
Views: 15824

Re:

... work together and in such a way that fitness does declines less rapidly with with a few detrimental mutations, and declines more rapidly as more accumulation. Basically, I guess this means organisms are tolerant of a suitably small number of detrimental effects. Jack made the point that living ...

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by ChrisHoStuart
Tue Oct 15, 2013 2:19 pm
 
Forum: Evolution
Topic: Beneficial mutations vs harmful
Replies: 12
Views: 7323

Gender divison in two opposites is greatest mistake of manki

... and the Origin of Menopause. PLoS Comput Biol 9(6): e1003092. doi:10.1371/journal.pcbi.1003092 . The idea is that menopause is the result of an accumulation of detrimental mutations, which become fixed because there is little selection AGAINST them; due to the mating preference against older ...

See entire post
by ChrisHoStuart
Tue Oct 15, 2013 12:18 pm
 
Forum: Evolution
Topic: Gender divison in two opposites is greatest mistake of manki
Replies: 24
Views: 15824

Beneficial mutations vs harmful

... everywhere, beneficial mutations are eventually the ones that have best chances to prevail. However, in steady environments this kind of accumulation of tiny beneficial traits is extremely slow. However, like JackBean wrote, if the environment becomes drastically different, then certain ...

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by biohazard
Tue Oct 08, 2013 12:39 pm
 
Forum: Evolution
Topic: Beneficial mutations vs harmful
Replies: 12
Views: 7323

Re: Why must we avert the genome of Eden?

... bacterium) and genetic complexity and all the additional information accumulated over the course of evolution, we should be able to trace this accumulation by examining the genomes of different organisms on different levels of complexity. This is a reasonable expectation. (If we wouldn't know ...

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by wildfunguy
Fri Oct 04, 2013 7:49 pm
 
Forum: Evolution
Topic: Why must we avert the genome of Eden?
Replies: 6
Views: 7131
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