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ATP synthetase


noun, plural: ATP synthetases

An enzyme that catalyzes the formation of ATP from the phosphorylation of ADP with inorganic phosphate, using a form of energy.


This enzyme consists of two major segments: Fo portion, the transmembrane proton channel and F1 portion, the catalytic component. The proton channel component allows the diffusion of protons (hydrogen ions) from an area where there are more hydrogen ions to an area where there are less hydrogen ions due to a proton gradient. As the proton (H+ ion) moves down the concentration gradient this moves the enzyme in a spinning motion, which brings ADP and inorganic phosphate together to form a bond, thus creating ATP molecule. The resulting ATP molecule is released so that a new ADP molecule can enter for another phosphorylation.

See also: chemiosmosis

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Glutamine synthetase in animals

Yes. Check out GenBank http://www.ncbi.nlm.nih.gov/nuccore. Enter "glutamine synthetase" (with the quotation marks) and any animal whose genome has been sequenced, e.g. "Homo sapiens", "Caenorhabditis elegans".

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by wbla3335
Sat Jan 12, 2013 2:15 pm
Forum: Molecular Biology
Topic: Glutamine synthetase in animals
Replies: 2
Views: 1678

Glutamine synthetase in animals

Hi everybody I've been looking for a while now, and haven't come across this anywhere. Is glutamine synthetase (enzyme synthesizing glutamine from glutamate and ammonia) present in heterotrophs, e.g animals? This is quite a big deal, because it is the primary pahtway of ammonia ...

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by miikaelf
Sat Jan 12, 2013 12:33 pm
Forum: Molecular Biology
Topic: Glutamine synthetase in animals
Replies: 2
Views: 1678

what's the different betweent synthetase and synthases?

i only know one consumes ATP and another dn't, but what's more?

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by yesiao
Tue Apr 03, 2012 6:03 am
Forum: General Discussion
Topic: what's the different betweent synthetase and synthases?
Replies: 1
Views: 1003

A2 nitrogen fixation + denitrification

* there are several enzymes glutamine synthase and synthetase, I think. One is working with low NH3 conc. (and must use ATP), whereas the other is more useful with higher conc., when it runs faster ;)

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by JackBean
Mon Jan 18, 2010 10:27 am
Forum: Ecology
Topic: A2 nitrogen fixation + denitrification
Replies: 12
Views: 12837

Re: Signaling between the ribosome and synthetase

As far as I know there is no signaling between ribosome and synthetase. tRNAs linked to amino acids are present in the cytosol. The ribosome uses them, stripping off the amino acids. When an aminoacyl-tRNA synthetase encounters an unloaded tRNA, it puts ...

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by jonmoulton
Tue Jun 23, 2009 11:02 pm
Forum: Genetics
Topic: Signaling between the ribosome and synthetase
Replies: 3
Views: 3325
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