Dictionary » A » ATP synthase

ATP synthase


noun, plural: ATP synthases

An enzyme that catalyzes the formation of ATP from the phosphorylation of ADP with inorganic phosphate, using a form of energy, such as the energy from a proton gradient.


This enzyme consists of two major segments: Fo portion, the transmembrane proton channel and F1 portion, the catalytic component. The proton channel component allows the diffusion of protons (hydrogen ions) from an area where there are more hydrogen ions to an area where there are less hydrogen ions due to a proton gradient. As the proton (H+ ion) moves down the concentration gradient this moves the enzyme in a spinning motion, which brings ADP and inorganic phosphate together to form a bond, thus creating ATP molecule. The resulting ATP molecule is released so that a new ADP molecule can enter for another phosphorylation.

This enzyme can also work in reverse using the energy release from ATP hydrolysis to pump protons against their thermodynamic gradient. Since it can also use ATP as a source of energy it is also aptly called ATP synthetase.

See also: chemiosmosis

Please contribute to this project, if you have more information about this term feel free to edit this page

Results from our forum

Exp. antisense treatment for Pompe disease

Here's a nice preclinical report of antisense as a potential therapeutic. Antisense Oligonucleotide-mediated Suppression of Muscle Glycogen Synthase 1 Synthesis as an Approach for Substrate Reduction Therapy of Pompe Disease. Clayton NP, Nelson CA, Weeden T, Taylor KM, Moreland RJ, Scheule RK, ...

See entire post
by jonmoulton
Wed Oct 29, 2014 3:58 pm
Forum: Genetics
Topic: Exp. antisense treatment for Pompe disease
Replies: 0
Views: 501

Re: Mitochondrial DNA

... such as the ETC (Electron Transport Chain) proteins such as ATP synthase and it's own ribosomal genes. Here is a pretty good representation of what mtDNA looks ...

See entire post
by Zargo
Sun Sep 07, 2014 5:02 am
Forum: Genetics
Topic: Mitochondrial DNA
Replies: 6
Views: 3784

Re: Number of water molecules produced by cellular respiration

... show is that during the Kreb's cycle and specifically during the combination reaction of acetylCoA plus oxaloacteate to form citrate via citrate synthase that a single water molecule is consumed. That is one additional water consumption per acetyl CoA then typically illustrated or 2 water consumptions ...

See entire post
by thornthor
Sun Nov 03, 2013 5:48 pm
Forum: Cell Biology
Topic: Number of water molecules produced by cellular respiration
Replies: 8
Views: 16829

I need some help understanding mitochondria

... of the proteins found in a cell in the mitochondria? Why & how do ATP synthase in the inner membrane and use the concentration gradient to produce ATP? and what ...

See entire post
by fightclub
Sat Oct 06, 2012 8:44 pm
Forum: Cell Biology
Topic: I need some help understanding mitochondria
Replies: 1
Views: 4814

Role of membranes in synthesis of ATP in cellular respiratio

... to do my homework ----Membranes play a huge role in the synthesis of ATP in the mitochondria, the power house of the cell. Mitochondria are composed ... the diffusion of hydrogen ions across the membrane using the ATP synthase (a transport protein). This protein uses the power of hydrogen ions ...

See entire post
by mkbeast99
Wed Aug 15, 2012 11:12 pm
Forum: Molecular Biology
Topic: Role of membranes in synthesis of ATP in cellular respiratio
Replies: 1
Views: 19647
View all matching forum results

This page was last modified 10:10, 23 June 2009. This page has been accessed 54,199 times. 
What links here | Related changes | Permanent link