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Structural Bioinformatics (Methods of Biochemical Analysis, V. 44)

 Structural Bioinformatics (Methods of Biochemical Analysis, V. 44)  

   

AUTHORS: 

  • Philip E. Bourne 
  • Helge Weissig

PRODUCT DETAILS:

  • Paperback: 672 pages
  • Publisher: Wiley-Liss (February 21, 2003)
  • Language: English
  • ISBN: 0471201995
  • Product Dimensions: 10.1 x 7 x 1.3 inches
  • Shipping Weight: 2.66 pounds
EDITORIAL REVIEWS

Book Description

From the Foreword…
"[A] must read for all of us committed to understanding the interplay of structure and function...[T]he individual chapters outline the suite of major basic life science questions such as the status of efforts to predict protein structure and how proteins carry out cellular functions, and also the applied life science questions such as how structural bioinformatics can improve health care through accelerating drug discovery."

This book provides a basic understanding of the theories, associated algorithms, resources, and tools used in structural bioinformatics. The reader emerges with the ability to make effective use of protein, DNA, RNA, carbohydrate, and complex structures to better understand biological function. Moreover, it draws a clear connection between structural studies and the rational design of new therapies. 

Book Info

Univ. of California, San Diego. Text covers theory, biology, resources, and practical applications for computational approaches to biomolecular structural studies. Also includes computational analysis of pharmacogenomics and discussions on on drug design. Softcover, hardcover available. DNLM: Computational biology. 

From the Author

This book includes chapters from many of the leaders in the field and is intended to serve as a reference text for graduate students undertaking bioinformatics as a major or any established scientist wishing to understand the field at a time when biological structure is key to our understanding of living systems. --This text refers to an out of print or unavailable edition of this title.

From the Inside Flap

The emerging discipline of structural bioinformatics comprises the development of computational technologies for methods of storage, retrieval, and analysis of the three-dimensional structure of biological macromolecules. Edited by Philip Bourne and Helge Weissig, this groundbreaking text provides a thorough understanding of the theories, associated algorithms, resources, and tools used in structural bioinformatics.

Structural Bioinformatics begins with chapters on the fundamentals of protein structure, DNA/RNA structure, carbohydrates, and techniques including X-ray crystallography, NMR, cryo-electron microscopy, and molecular visualization. The next section addresses data representation and databases, followed by information on structure classification of proteins (SCOP) and class, architecture, topology, and homology (CATH) classification. Later chapters cover structure-function assignment, protein interactions, and proteins as drug targets. Structural Bioinformatics also:

  • Covers the theory, biology, resources, and practical applications for computational approaches to biomolecular structural studies
  • Provides broad-based, concise coverage with a consistent direction
  • Offers detailed coverage for practitioners while remaining accessible to the novice
  • Presents computational analysis of growing masses of structural data as the key to advances in pharmacogenomics

The book concludes with several chapters on structure prediction methods, and discussion of the future of high-throughput structure determination in drug design.

Readers will gain the ability to make effective use of protein, DNA, RNA, carbohydrate, and complex structures to better understand biological function. Molecular biologists, biochemists, biophysicists, and bioinformaticians in basic and clinical research, as well as undergraduate and graduate students in biology, medicine, and computer science, will find Structural Bioinformatics to be an essential addition to their professional and academic libraries. --This text refers to an out of print or unavailable edition of this title.

From the Back Cover

Structural Bioinformatics begins with chapters on the fundamentals of protein structure, DNA/RNA structure, carbohydrates, and techniques including X-ray crystallography, NMR, cryo-electron microscopy, and molecular visualization. The following section addresses data representation and databases, followed by information on structure classification of proteins (SCOP) and class, architecture, topology, homology (CATH) classification. Later chapters cover structure-function assignment, protein interactions, and proteins as drug targets. Structural Bioinformatics also:

  • Covers the theory, biology, resources, and practical applications for computational approaches to biomolecular structural studies
  • Provides broad-based, concise coverage with a consistent level and direction
  • Offers detailed coverage for practitioners while remaining accessible to the novice student
  • Presents computational analysis of growing masses of structural data as the key to advances in pharmacogenomics

The book concludes with several chapters on structure prediction methods and a discussion of the future of high-throughput structure determination in drug design.

Molecular biologists, biochemists, biophysicists, and bioinformaticians in basic and clinical research, as well as undergraduate and graduate students in biology, medicine, and computer science will find Structural Bioinformatics an essential addition to their bookshelves.

About the Author

PHILIP E. BOURNE is a Professor in the Department of Pharmacology at the University of California San Diego and Director of Integrated Biosciences at the San Diego Supercomputer Center. He is also currently the President of the International Society for Computational Biology (ISCB). Dr. Bourne is the author of over 100 peer reviewed scientific papers and three previous books.

HELGE WEISSIG is a Project Leader in Bioinformatics at ActivX Biosciences, a proteomics company, and also co-coordinates the Bioinformatics Certificate program for UCSD Extension. After doing his post-doctoral work with Prof. Bourne at the San Diego Supercomputer Center, he became the Technical Project Manager for the RCSB Protein Data Bank (PDB) at UCSD.

CUSTOMER REVIEWS

A Legit review from a REAL: reader, June 16, 2006 

Ok, there are 3 reviews listed here from what seems to be the authors or their closest friends... I give these about as much credit as whale dung at the bottom of the ocean. That being said, this *IS* an awesome summation of current knowledge in the fields of Structural biology and bioinformatics, especially for one with a working (undergraduate) knowledge of biological building blocks.
A few things of note: the book is aimed at biologists. This is not to imply that computer scientists or actuarial scientists will never understand this book, but rather implies that the approach to instruction is taken from the biological realm and then expanded to other related fields.
Also note that this is aimed strictly at comparative structural bioinformatics. While mentioned in the book, topics like transcription factors, x-ray crystalographic methods, or multi-cell signalling networks are best left for other books. This particular book, while touching on the subjects, does not go into much depth in these subjects. Personally, I feel this is all the better, allowing for a better primer of the subjects.
All in all, I have to say that this is one of the best books to date for an upper-undergraduate / graduate student to gain a working knowledge of Structural Bioinformatics. As such, I gladly rate this a 5 star book!


Rating: not rated | Added on: 7 Dec 2006

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