(Science: chemical) 9,15-dihydroxy-11-oxoprosta-5,13-dien-1-oic acid. The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesised by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.
Chemical name: Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9alpha,13E,15S)-