Classification of non-coding RNA

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Classification of non-coding RNA

Post by raghavagps » Sat Feb 15, 2014 3:39 pm

We wish to share RNAcon, a web-server for the prediction and classification of non-coding RNAs. It uses SVM-based model for the discrimination between coding and ncRNAs and RandomForest-based prediction model for the classification of ncRNAs into different classes. The structural information based graph properties were used for the development of prediction model.


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Post by leesajohnson » Thu Sep 15, 2016 7:04 am

Non-coding RNA (ncRNA) is just RNA that doesn't code for protein. Historically the "Central Dogma" defines a process of protein creation that goes from DNA --> RNA --> Protein in the cell. All ncRNA stops before being translated to protein.So non-coding RNA is usually split up into two categories: long and short. How long and how short is usually debatable but long non-coding RNA (lncRNA) is usually defined to be > 200 nt. Historically, much of the genome and transcriptome was thought to be "junk." In fact you will often hear the term "junk DNA." Recently, however, that thought paradigm is shifting and a lot of new types of mechanisms are being discovered that utilize ncRNA transcribed from DNA that was previously thought to be "junk." It's probably more helpful to see examples of both short and long ncRNA .

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Re: Classification of non-coding RNA

Post by rahilsaxena » Thu Dec 13, 2018 9:30 am

One of the long-standing principles of molecular biology is that DNA acts as a template for transcription of messenger RNAs, which serve as blueprints for protein translation.
A rapidly growing number of exceptions to this rule have been reported over the past decades: they include long known classes of RNAs involved in translation such as transfer RNAs and ribosomal RNAs, small nuclear RNAs involved in splicing events, and small nucleolar RNAs mainly involved in the modification of other small RNAs, such as ribosomal RNAs and transfer RNAs.
More recently, several classes of short regulatory non-coding RNAs, including piwi-associated RNAs, endogenous short-interfering RNAs and microRNAs have been discovered in mammals, which act as key regulators of gene expression in many different cellular pathways and systems. Additionally, the human genome encodes several thousand long non-protein coding RNAs >200 nucleotides in length, some of which play crucial roles in a variety of biological processes such as epigenetic control of chromatin, promoter-specific gene regulation, mRNA stability, X-chromosome inactivation and imprinting. In this chapter, we will introduce several classes of short and long non-coding RNAs, describe their diverse roles in mammalian gene regulation and give examples for known modes of action.
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