Bioinformatics Handbook for Life Scientists

Everything on bioinformatics, the science of information technology as applied to biological research.

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Bioinformatics Handbook for Life Scientists

Post by biostar2 » Sun Aug 13, 2017 4:15 pm

Hello Everyone,

We'd like to announce the availability of a bioinformatics training resource: The Biostar Handbook.

The Biostar Handbook introduces readers to bioinformatics, the scientific discipline at the intersection of biology, computer science, and statistical data analytics that is dedicated to the digital processing of genomic information:

The contents of this book have provided the analytical foundation to hundreds of students, many of whom have become full-time bioinformaticians and work at the most innovative companies in the world.

best regards,


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Re: Bioinformatics Handbook for Life Scientists

Post by rahilsaxena » Tue Dec 18, 2018 5:43 am

Epitope, also called antigenic determinant, portion of a foreign protein, or antigen, that is capable of stimulating an immune response. An epitope is the part of the antigen that binds to a specific antigen receptor on the surface of a B cell. Binding between the receptor and epitope occurs only if their structures are complementary. If they are, epitope and receptor fit together like two pieces of a puzzle, an event that is necessary to activate B-cell production of antibodies. The antibodies produced by B cells are targeted specifically to the epitopes that bind to the cells’ antigen receptors. Thus, the epitope also is the region of the antigen that is recognized by specific antibodies, which bind to and remove the antigen from the body.
Many antigens have a variety of distinct epitopes on their surfaces. Each epitope is capable of reacting with a different B cell antigen receptor. In addition, the blood serum of an immunized person or animal normally contains a mixture of antibodies, all capable of combining with the same antigen but with different epitopes that appear on the surface of the antigen. Furthermore, antibodies that bind to the same epitope often have different abilities to bind to that epitope.
It is possible for two or more different antigens to have an epitope in common. In these cases, antibodies targeted to one antigen are able to react with all other antigens carrying the same epitope. Such antigens are known as cross-reacting antigens.
Clinical Research

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