If there is a greater amount of activated T lymphocytes, doe

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Alexmopan
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If there is a greater amount of activated T lymphocytes, doe

Post by Alexmopan » Mon Sep 04, 2017 8:55 pm

Molecular analysis of human tumors demonstrated that cell cycle regulators have frequently mutated in human malignancies, highlighting the prominence in maintaining cell cycle involvement in the prevention of human cancer. Cell cycle regulation is a markedly complex process with many control phases and one of these multiple mechanisms involves the degradation of CDK inhibitors (CKIs) as p27Kip1 by the ubiquitin proteasome system (UPS). Cks1 is a 9 kDa protein that is frequently overexpressed in several tumor subtypes and has pleiotropic functions in cell cycle progression, this protein is a regulator of cyclin-dependent protein kinase, the same component on which the inhibitory protein of the CDKN1B cell cycle encoded by the p27Kip1 gene also depends.
It has been shown that IL-2 protein causes a reduction in p27Kip1 levels. This protein is produced by activated T lymphocytes. My question is whether increasing IL-2 protein production could decrease production of the CDKN1B protein synthesized by p27Kip1, since a mutation in this gene could lead to loss of control over the cell cycle, causing uncontrolled cell proliferation.

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