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Need help to understand this harvey weinburg problem!!Moderator: BioTeam
5 posts • Page 1 of 1
Need help to understand this harvey weinburg problem!!A very large population of lab mice contains 35% white mice. White coloring is caused by the double recessive genotype "aa". Calculate allelic and genotypic frequencies for this population.
a.Homozygous dom genotype: b.Homezygous recces genotype: c.Heterozygous genotype: d.Dominant allele frequency: e.Recessive allele frequency: Is there an easy way to calculate this problem? I have tried and am not sure if I am correct.....this is very confusing!!! Please help!! Here is my calculation: aa~ .59 (q2) A ~ 1.0 (p) AA~ .17 (p2) Aa~.48 (2pq)
Got the right idea, but I think you’ve misidentified one of the frequencies. You’re given the frequency of the homozygous recessive genotype, aa. But Pr[aa]=q2=0.35 (not 0.59).
Pr[aa]=0.35 (given) Pr[a]=q=sqrt(.35)=0.59 Pr[A]=p=1q=10.59=0.41 Pr[AA]=p2=(0.41)(0.41)=0.17 Pr[Aa]=2pq=2(.59)(.41)=0.48 Check p2 + 2pq + q2 = 1 = 0.35 + 0.48 + 0.17 Frequency of: Homozygous dominant genotype (AA): p2=0.17 Homozygous recessive genotype (aa): q2=0.35 Heterozygous genotype (Aa): 2pq=0.48 Dominant allele (A): p=0.41 Recessive allele (a): q=0.59 I think you were OK except for confusing Pr[aa] with Pr[a].
Thank you for clearing that up!!Thank you so much! I see where I made the mistake.
5 posts • Page 1 of 1
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