RNA VS ENZYMES

[2810712]

I think, many of us R familier with the hypothesis of RNA world . I was wondering if we create an RNA-catalyst , because if we get such a thing it will certainly prooove the hypothesis. I M very interested in this field & request U all to recomend me useful sites regarding this.
THANKS!!!!

[thank.darwin]

. I was wondering if we create an RNA-catalyst , because if we get such a thing it will certainly prooove the hypothesis.

What do you mean - If we create an RNA- catalyst - Are you asking whether or not they can be created? or if they exists?

[canalon]

RNA-catalyst? You mean self replicating RNA? RNA with enzymatic abilities?
I don't know for the first, but for the latter, I suggest you look for Ribozymes. They are catalytic RNA, and are indeed a strong foundation for the RNA world hypothesis.

[thank.darwin]

RNA with enzymatic abilities?

There are RNA enzymes out there you know...

[prometheusmax]

I think, many of us R familier with the hypothesis of RNA world . I was wondering if we create an RNA-catalyst , because if we get such a thing it will certainly prooove the hypothesis. I M very interested in this field & request U all to recomend me useful sites regarding this.
THANKS!!!!

This article in interesting and relevant to your question:
This article from Virology Journal (http://www.virologyj.com/home) might be of interest to the readership as it (among other things) describes a mechanism that enables protein information to modify RNA information, and is a mechanism of Larmarkian inheritance. The author makes it clear that it remains consistent with Darwinian selection. It also suggest potential weaknesses in viral replication that might be exploited.
Hepatitis C (HCV), hepatitis B (HBV), the human immunodeficiency viruses (HIV), and other viruses that replicate via RNA intermediaries, cause an enormous burden of disease and premature death worldwide. These viruses circulate within infected hosts as vast populations of closely related, but genetically diverse, molecules known as "quasispecies". The mechanism(s) by which this extreme genetic and antigenic diversity is stably maintained are unclear, but are fundamental to understanding viral persistence and pathobiology. The persistence of HCV, an RNA virus, is especially problematic and HCV stability, maintained despite rapid genomic mutation, is highly paradoxical. This paper presents the hypothesis, and evidence, that viruses capable of persistent infection autoregulate replication and the likely mechanism mediating autoregulation--Replicative Homeostasis--is described. Replicative homeostasis causes formation of stable, but highly reactive, equilibria that drive quasispecies expansion and generates escape mutation. Replicative homeostasis explains both viral kinetics and the enigma of RNA quasispecies stability and provides a rational, mechanistic basis for all observed viral behaviours and host responses. More importantly, this paradigm has specific therapeutic implication and defines, precisely, new approaches to antiviral therapy. Replicative homeostasis may also modulate cellular gene expression.

[mith]

Ummm why are you posting the same article 4 times to different questions?

[robotics]

I'd say at least 99 percent of all enzymes are proteins, but you're right, there are some RNA catalysts.

RNA-catalyst? You mean self replicating RNA? RNA with enzymatic abilities?
I don't know for the first, but for the latter, I suggest you look for Ribozymes. They are catalytic RNA, and are indeed a strong foundation for the RNA world hypothesis.

Exactly what he said Look for something like Ribozymes, they have enzyme-like properties (can serve as a catalyst, lowering activation energies of reactions, etc) but are in fact RNA.

The RNA hypothesis certainly explains a lot of things, and also suggests a plausible explanation for how DNA came to arise. I can see why you're interested in that field

[2810712]

R ribozymes same as enzymes [ in properties except building blocks ] ?
The RNA hypothesis certainly explains a lot of things, and also suggests a plausible explanation for how DNA came to arise. I can see why you're interested in that field
- intelligent

hrushikesh