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Receptor

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Receptor

Postby Fricas » Sat Feb 17, 2007 1:25 pm

Hello,
I wonder can receptor adapt to the stimulation and what other specific features it has apart from data (that got from environment) sending to the brains.
Thanks!
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Postby dipjyoti » Sat Feb 17, 2007 3:20 pm

Yes, but specific. Adaptation, or fatigue, to constant stimulation is a general feature of sensory systems. For instance, the touch receptor cells in the skin adapt to the stimulation of our clothes, a fortunate thing, or we would be distracted by them constantly. Adaptation involves mechanisms at the level of the receptor cell, including the inactivation of ion channels in the membrane that generate the electrical signal. In a simplified explanation, after a stimulus causes a receptor cell to produce an electrical signal, the cell membrane soon stops allowing ions to flow, thus preventing further signals. Removal of the stimulus followed by restimulation activates the process all over again.

Researchers have noted that people adapt to odors, such as the smell of tobacco smoke in a room, more quickly than the properties of olfactory receptor cells would predict. Thus, they believe that olfactory fatigue involves some types of central nervous system mechanisms as well as receptor adaptation. Although these brain mechanisms are currently unknown, scientists speculate that inhibitory circuits in the brain "quash" the incoming sensory signals from receptors before they reach conscious levels.


Sensory receptors respond to specific stimulus modalities. The stimulus modality to which a sensory receptor responds is determined by the sensory receptor's adequate stimulus.

Thank You.
Dip Jyoti Chakraborty.
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Postby sdekivit » Sat Feb 17, 2007 4:01 pm

receptor up- and downregulation ;)
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Postby satrohraj » Sat Feb 17, 2007 8:49 pm

Yes, they adapt (as said by dipjyoti)
and even evolve in course of time (thousands of years)
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Postby dipjyoti » Sun Feb 18, 2007 9:12 am

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Postby Dr.Stein » Mon Feb 19, 2007 5:35 am

sdekivit wrote:receptor up- and downregulation ;)

Aha! Nice to hear this term again after looong times ;)
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Postby radu » Mon Feb 19, 2007 11:38 am

yap...that's the mechanism for developing drug tolerance.
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Postby satrohraj » Mon Feb 19, 2007 1:29 pm

radu wrote:yap...that's the mechanism for developing drug tolerance.


another good example...
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Postby sdekivit » Tue Feb 20, 2007 8:54 pm

Dr.Stein wrote:
sdekivit wrote:receptor up- and downregulation ;)

Aha! Nice to hear this term again after looong times ;)


very nice terms :D i investigated these phenomena on rat ileum in relation with mast cell degranulation.
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Postby whirlboy » Thu Feb 22, 2007 3:58 pm

Not the same as the drug tolerance.
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Postby radu » Thu Feb 22, 2007 4:24 pm

Receptor downregulation is the mechanism for pharmacodynamic drug tolerance (for example opioids or benzodiazepins). Also there is pharmacokinetic drug tolerance (for barbiturates) wich has nothing to do with receptors, but with the drug increasing its own metabolization by the liver.
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Postby Dr.Stein » Fri Feb 23, 2007 4:18 am

Up- and down-regulation of receptor actually are not just for drugs stuff but also for anything that has relationship with receptor:ligand mechanism :)

@sdekivit: I really want to come by your lab and watching you making experiment :(
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