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The Fiber Disease

Human Anatomy, Physiology, and Medicine. Anything human!

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Postby Frank N Stein » Wed Jan 03, 2007 12:30 pm

One quick thought before I head out the door regarding activism and things that we may actually be able to achieve.

One of the greater problems that we experience is the actual recognition of this disease. I have been told by a physician that the reason we are diagnosed as DP is that medical students are trained to follow a strict protocol that requires that any patient whom is self diagnosing an affliction that does not “medically exist” be considered as DP. Also, even if a physician believes the patient, they still have to get paid. If a patient is paying with insurance, a code for a recognized physical problem has to be applied to the physician’s paperwork as a condition of getting paid. At present, there is no code for unknown skin disease.

I believe that the simple solution to this is to get the CDC to acknowledge that some medical condition is indeed affecting us. They don’t have to identify it, but rather just acknowledge that it exists. Perhaps this is an issue for our elected representatives.

What are your thoughts on this? Randy? Anyone????????

If you’re bored Al, perhaps you could get busy with your Congressman.
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Postby Barz » Wed Jan 03, 2007 1:15 pm

It is thought by some that the reasoning behind the DOP label is that the doctors are able to prescribe anti-psychotic drugs which also have anti-helmith properties. Therefore, when ones symptoms improve, they can all say see, YOU ARE CRAZY!!!!!!!!
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Postby Marcos » Wed Jan 03, 2007 8:51 pm

To reduce time, the English translation of Tam-tam's Spanish

In all case, single two fungi of medical importance, Phythium insidiosum and Rhinosporidium seeberi is encuantran in first of them, although it is possible that the Prototheca alga wickerhamii, person in charge of sporadic cases of subcutaneous infection, also finish including itself in this group.

That is thought by some, Barz, but doctors aren't that preoccupied with us.
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Postby tamtam » Thu Jan 04, 2007 3:27 am

/////////////forward///////////////
Last edited by tamtam on Thu Jan 04, 2007 2:43 pm, edited 1 time in total.
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Postby Linn » Thu Jan 04, 2007 3:29 am

RANDY wrote:http://www.thenmo.org/er-dop.htm

Interesting stuff to read.

Happy New Year to all!


Thanks Randy this is a good site.
from that I found this on DOP diagnosis:

http://www.thenmo.org/DOP/MgD-dop0b_files/frame.htm

If any one looks at this power point presentation, please will you tell me about
#58 image of dog with morgellons because I can not see the image for some reason.

My thinking is how can it be DOP in a dog????? :wink: :roll:
"How far you go in life depends on your being tender with the young, compassionate with the aged, sympathetic with the striving and tolerant of the weak and strong. Because someday in life you will have been all of these".

~ George washington Carver
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Postby Maggie Mae » Thu Jan 04, 2007 6:34 am

http://216.239.51.104/search?q=cache:n3 ... =clnk&cd=1

Came upon this while researching...is this possible???

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Postby Serenity » Thu Jan 04, 2007 1:19 pm

Dear msc

Happy New Year. I posted a few weeks ago and have been reading ever since. Thank you to Tam Tam for dumbing down her posts a bit so even the average genius can comprehend.

I have this illness. I have not wanted to say those words outloud. I was in denial for a while. I could not accept what my eyes were seeing and tried to find all and any logical explanation for movement of these strands after being plucked. It was not until I watched one move in a corkscrew like motion as if to burrow itself into anything in air around it, that I had my reality check.

I threw up.

I had Lyme some 10 years ago and after a few rounds of antibiotics...
some 10 to 12 weeks, I really felt better.
I don't think I have this as badly as some. I am not debilitated although I do fight fatigue and sometimes have difficulty with focus. I attributed these symptoms to menopause.

My husband is a senior corporate executive and a pragmatist.
There is no way on earth I could ever begin to explain this to him.
My children would listen but in the end they would think mom needs a check up from the neck up.

I am a former ICU nurse.

Anyway....I went the Avermectin route. I won't give you all the gory details but I am so upset. There are strands in my urine which means this is a blood borne microfilariasis.

I had bought Borax for disinfecting but now can't find in stores in my area.
I bought a Hepa-vac as well.

I have little to offer this forum. I just needed to vent. I am disgusted by this stuff. I have seen white fibers launch from me when I was at my gym, in a dressing rrom at a store and at my daughters basketball game.
They just waft in the air around me.

I can say that the skin fibers are gone now but as I said I am still passing in my urine.

This is strange indeed.

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Postby Serenity » Thu Jan 04, 2007 2:02 pm

I was wondering if there is any common denominator amoung individuals effected with this creepy crawly crap. Prehaps blood type? I am O neg.
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Postby tamtam » Thu Jan 04, 2007 2:45 pm

Its all about infection with a very difficult to culture and highly modified micro organism.
Last edited by tamtam on Thu Jan 04, 2007 2:48 pm, edited 2 times in total.
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Postby tamtam » Thu Jan 04, 2007 2:46 pm

Excerpt from this important article:

Confidence in predicting significantly more algal species than are recognized now is based upon the annual rate of new species descriptions, the large geographical areas that to date have been only poorly explored phycologically, and the morphological similarity that frequently masks genetic diversity, notably among coccoid picoplankton (373)
Even the most cursory glance at the literature illustrates the pace and range of new microorganism discovery: completely novel bacteria being found in such commonplace environments as activated sludge (7, 178, 347), caves (191), and the human gut (430); novel rickettsial endosymbionts in common soil and water amebae (145); and high bacterial and genetic diversity in deep-sea sediments (79, 80, 290, 382). However, this brief survey also raises several general issues of importance for the biotechnology search activity.
"Such revisions are evident not only at lower taxonomic levels but also at division (e.g., pseudomonads [261]) and order (e.g., Chlamydiales [121, 398]) levels. Gene sequencing studies can also be used to resolve the phylogenetic position of so-called enigmatic organisms. In recent years the putative protozoan Epulopiscium fishelsoni has been proved to be an unusually large bacterium (13), the putative alga Prototheca richardsi has been demonstrated to be a member of a newly recognized clade near the animal-fungal divergence point (24), and microsporidia appear to be related to fungi rather than being early-diverging

Several authors have commented recently on the use—or misuse—of rDNA sequence data as the sole descriptor for establishing a taxon (336) or for suggesting that a single molecular marker can serve to reveal phylogenetic relationships of bacteria (162).eukaryotes (213)"

i.e., the ratio of known metabolites to species richness of a particular taxon (112); (iii) focus on novel and neglected taxa, examples of which are evident in the previous section of this review; (iv) highlight isolates from unusual or little-explored ecosystems, e.g., mycoparasites (485); and (v) match the target with members of previously unscreened but known taxa, e.g., the human immunodeficiency virus (HIV)-inactivating protein cyanovirin-N as a result of screening cyanobacteria (49, 50).
One prerequisite to natural-product discovery that remains paramount is the range and novelty of molecular diversity. This diversity surpasses that of combinatorial chemical libraries and consequently provides unique lead compounds for drug and other developments. Newly discovered bioactive products do not usually become drugs per se (345, 449) but may enter a chemical transformation program in which the bioactivity and pharmacodynamic properties are modified to suit particular therapeutic needs. Several reviews are available that detail important recent developments in this field (75, 212, 271).

There is a strong view that biopharmaceutin leads are more likely to be detected in cell function assays than in in vitro assays (210). In this context, construction of surrogate host cells for in vivo drug screening is an interesting development. For example, the ability of Saccharomyces cerevisiae to express heterologous proteins makes it an attractive option; its use in screens based on substitution assays, differential expression assays, and transactivation assays is proving to be an effective route to drug discovery. The procedures involved and the future for S. cerevisiae as a tool for targeted screening have been discussed recently by Munder and Hinnen (334).

The Paradigm Shift

"typical of any new technology: a slow initial phase followed by a period of rapid growth (selectively in biotechnology, where it has occurred predominantly in the health care sector) and entry into a mature phase of consolidation and penetration. Thus, biotechnology currently can be defined as a robust, reliable, and relatively low risk technology (current debates on genetically modified organisms notwithstanding) and capable of being implemented on a large scale and across the full range of industrial sectors"


Search and Discovery Strategies for Biotechnology: the Paradigm Shift
All the available evidence points to natural-product discovery continuing strongly and accelerating as a consequence of new search strategies and innovative ...

http://www.pubmedcentral.nih.gov/articl ... rtid=99005
Last edited by tamtam on Thu Jan 04, 2007 3:11 pm, edited 1 time in total.
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Postby tamtam » Thu Jan 04, 2007 3:10 pm

Related article:

(Prototheca/ DRIP clade)

"Unassigned"

Prototheca richardsi, a pathogen of anuran larvae, is related to a clade of protistan parasites near the animal--fungal divergence

http://mic.sgmjournals.org/cgi/content/ ... 145/7/1777

http://mic.sgmjournals.org/cgi/reprint/145/7/1777.pdf


"The two Dermocystidium species resemble Rhinosporidium
seeberi (as described by light microscope), a member of the nearest relative genus, but differ in that in R. seeberi plasmodia have thousands
of nuclei discernible, endospores are discharged through a pore in the wall of the sporangium, and zoospores have not been revealed"



[PDF]
Phylogenetic Position and Ultrastructure of Two Dermocystidium ...
File Format: PDF/Adobe Acrobat - View as HTML
the Dermocystidium-Rhinosporidium clade within Ichthyosporea, D. fennicum as a specific sister ... Ichthyosporea (see references to description of different ...
http://www.nencki.gov.pl/pdf/ap/ap718.pdf - Similar pages


(Mesomycetozoean = Ichthyosporea)

Taken together, these characteristics clearly distinguish it from the closely related genera Dermocystidium and Rhinosporidium.

Observations on the Life Stages of Sphaerothecum destruens n. g., n. sp., a Mesomycetozoean Fish Pathogen Formally Referred to as the Rosette Agent
http://www.blackwell-synergy.com/doi/ab ... .tb00269.x

http://plantbio.berkeley.edu/~taylor/papers/mendoza2002.pdf
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Postby al » Thu Jan 04, 2007 10:21 pm

Morphological Observations on the Life Cycle of Dermocystidium cyprini Červinka and Lom, 1974, Parasitic in Carps (Cyprinus carpio)

Kaja LOTMAN1, Marketta PEKKARINEN2 and Juri KASESALU3
1Institute of Zoology and Hydrobiology, University of Tartu, Estonia; 2Department of Biosciences, Division of Animal Physiology, University of Helsinki, Finland; 3Institute of Animal Husbandry, Estonian Agricultural University, Tartu, Estonia




Summary. The genus Dermocystidium Pérez, 1908 has been assigned to the DRIPs clade near the animal-fungal dichotomy in 1996. The life cycle of Dermocystidium cyprini Červinka and Lom, 1974, the gill parasite of common carps, includes cysts with lipid-rich plasmodial stages, formation of sporonts by division of the plasmodia, and maturation of spores within the cysts. Motile zoospores appeared a few times in cultures of isolated cysts in vitro. Zoospores may develop from the spores or from sporoblasts without formation of the spore stage. Zoospores possibly escape from the cysts through pores in the cyst wall. The cyst wall comprises several strata. During plasmotomy the fibrous stratum of the wall is engulfed to form the walls of different compartments. Cells maturing into zoospores have a prominent inclusion, an eccentric nucleus, a few mitochondria and several membrane-surrounded bodies. The largest body has a quadruple membrane, and the smallest ones have ribosome-like inclusions. The flagellum of the zoospore has a striated rhizoplast penetrating to a ribosome-rich area in the zoospore cytoplasm. The functional kinetosome and rhizoplast are at an angle of 130 to 140o to each other, and a non-functional kinetosome seems to be at a right angle to the rhizoplast. Although the ciliary root with its associated structures of Dermocystidium cyprini bears some resemblance to that of some chytridiomycetes, the systematic position of the organism still remains unsettled.

Key words: Cyprinus carpio, Dermocystidium, development, parasite ultrastructure, zoospore.

Abbreviations: BB - basal body; CV - clear vacuole; D - desmosome; ED - electron dense stratum; ER - endoplasmic reticulum; F - flagellum; G - granular stratum;
GF - granular-fibrous stratum; I - inclusion; LD - lipid droplet; MC - mitochondrion; MT - microtubules; MVB - multivesicular body; Nu - nucleus; PC - phagocyte; Pl - plasmodium; Pr - prop; PS - plasmodium shoot; R - ribosomes; TF - transitional fibres; TZ - transitional zone; V - villus, villi; W - cyst wall.

Address for correspondence: Marketta Pekkarinen, Department of Biosciences, Division of Animal Physiology, University of Helsinki, P.O. Box 17, FIN-00014 Helsinki, Finland; Fax: 358-9-1917301; E-mail: marketta.pekkarinen@helsinki.fi


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