Human Anatomy, Physiology, and Medicine. Anything human!
Lacazia loboi and Rhinosporidium seeberi: a genomic perspective
Mendoza, L.; Vilela, R.; Rosa, P. S.; Belone, A. F. F. 2005
Revista Iberoamericana de Micologia 22(4): 213-216
In the past five years, with the use of molecular strategies the phylogenetic affinities of the two more resilient pathogens studied in medical mycology, Lacazia loboi and Rhinosporidium seeberi were finally deciphered. These studies found that L. loboi was the sister taxon to Paracoccidioides brasiliensis, and R. seeberi was closely related to protistan spherical aquatic fish pathogens, located at the point were animals diverged from the fungi, in the class Mesomycetozoea. These initial studies indicated that a molecular strategy was the ideal approach to further understand these anomalous pathogens. However, the limited amount of information gathered so far from few DNA sequences, although crucial to place these organisms in the tree of life and to take a glance to their ecological preferences, did not provide answers to other important traits. In the following pages we discuss a genomic perspective for both pathogens and the benefit that such information could generate to understand more about these two uncultivated pathogens.
Perhaps the most significant finding revealed by the DNA data was the recent report of host specific strains in the genus
R h i n o s p o r i d i u m . This study suggested that R. seeberi is not a monotypic genus but constituted of multiple strains
(species?) closely related to their hosts....
http://188.8.131.52/search?q=cache:Jc ... =clnk&cd=1
In June 1985 the Subcommittee on the taxonomic of Phototrophic Bacteria proposed that names of cyanobacteria described and validly published as blue-green algae under the International Code of Botanical Nomenclature are recognized as having been published under the Bacteriological Code (1990 Revision) .
In September 1986, the Judicial Commission agreed unanimously to recommend the following to the ICSB (now ICSP): those names of taxa of Cyanobacteria and Cyanophyta that are valid under the Botanical Code be considered valid under the Bacteriological Code for the purpose of preparing an acceptance list comparable to the Approved Lists of Bacterial Names . However, "Declarations of intent" by the Judicial Commission were not taken up by the ICSB (now ICSP). ?In 2003, the "Subcommitteee on the taxonomy of phototrophic bacteria"  proposed the preparation of a list of approved names of cyanobateria under the Bacteriological Code and a small committee was appointed to prepare such a list. However, such a list is not yet available.
Consequently, names of cyanobacteria described and validly published as blue-green algae under the International Code of Botanical Nomenclature have no standing in bacterial nomenclature, unless they are again described under the Rules of the Bacteriological Code (1990 revision).
A proposal for the unification of five species of the cyanobacterial genus Microcystis Kutzing ex Lemmermann 1907 under the Rules of the Bacteriological Code
S Otsuka, S Suda, S Shibata, H Oyaizu, S Matsumoto and MM Watanabe ?Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
Genomic DNA homologies were examined from six Microcystis (cyanobacteria) strains, including five different species, Microcystis aeruginosa, Microcystis ichthyoblabe, Microcystis novacekii, Microcystis viridis and Microcystis wesenbergii. All DNA--DNA reassociation values between two strains of M. aeruginosa and the other four species exceeded 70%, which is considered high enough for them to be classified within the same bacterial species. It is proposed to unify these five species into M. aeruginosa under the Rules of the Bacteriological Code and NIES843(T) (=IAM M-247(T)) is proposed as the type strain. Two other species, Microcystis flos-aquae and Microcystis pseudofilamentosa, should be regarded as morphological variations of this unified M. aeruginosa. The current taxonomy of cyanobacteria depends too much upon morphological characteristics and must be reviewed by means of bacteriological methods as well as traditional botanical methods.
http://ijs.sgmjournals.org/cgi/content/ ... t/51/3/873
The authors of the sections on the cyanobacteria in Bergey's Manual admit that the proposed classification is a temporary one that will undoubtedly require modification in the future. They state that many generic names used in the past (e.g. Synechococcus, Leptolyngbya, Pseudanabaena) will eventually have to be split into several new genera (Castenholz, 2001). This is especially true if molecular phylogenetic analyses based on sequence comparison of 16S rRNA and other relevant genes are used as the basis of taxonomy and nomenclature. Members of the orders Chroococcales, Pleurocapsales and Oscillatoriales do not form coherent phylogenetic lineages but instead are dispersed throughout the phylogenetic tree (Wilmotte, 1994; Wilmotte & Herdman, 2001).
My name is Nikki, I am a couple days new 2 this site. I am already overwhelmed w/ so much confusion on so many topics that could be the cause, but I came here 2 talk w/ others and share tips etc. to accomplish a goal of having our life back again, maybe even a cure. Well all I have received as of yet is mean plain mean, I have been scolded for using my CAPS come on I have real problems here, been accused of trying to sell knives,books etc. I have NOTHING to sell (we have all I'm quite sure spent way to much $$$ on dead end things as well as our energy that we need!!) and then people wonder why It's better to be on a personal level with somebody you really feel you can connect with and help each other out,
I can really understand why you want people ( the one's who are ONLY
really serious about fixing this not just complaining about it) by the way
I just joined your site that's A good thing for the New Year, I tried to phone
you last night but did not get through New Year's Eve and all, I will try again
best believe, you seem very real and sincere, I look forward to speaking
w/ you on a personal basis. I do have some tips on things that have really helped me and I want to share with others but as you can look and see after only 3 post I've been analyzed etc. by somebody who doesn't even know anything about me then want's to know why I have not publicly posted my tip's, I could only imagine, the funny thing is yesterday, I wrote this long letter about some of the tip's, I thought
I submitted it but looked back and it was nowhere on the site, I really
would of been torn into shreds just for trying to help( I looked back on the last 7 days and learned alot on the manner of this site)
Well Thank You for your time. We all need to stay STRONG.POSITIVE,
& SUPPORTIVE OF ONE ANOTHER, after all we ALL suffer from the same
nightmere right? So why??? not all try to be atleast close be to the same
page of one another!!!!!! Not be divided!!! Thankx"S Randy for some hope so far can't wait to talk
Thanks for the links- I took a few keywords from your posts and did some Googling-
http://www.palaeos.com/Eukarya/Units/Mi ... rosporidia
Bacchi, CJ, LM Weiss, S Lane, B Frydman, A Valasinas, V Reddy, JS Sun,
LJ Marton, IA Khan, M Moretto, N Yarlett, & M Wittner (2002), Novel
synthetic polyamines are effective in the treatment of experimental
microsporidiosis, an opportunistic AIDS-associated infection.
Antimicrob. Agents Chemother. 46: 55-61. Microsporidia.
My question is- it seems that I keep coming back to HIV/AIDS in researching R Sporidium. Is that where this leads?
Also, per the link below, does the paragraph that I excerpted have a bearing on our problem?
http://www.palaeos.com/Eukarya/Units/Mi ... rosporidia
Synthesis of the spore coats and sporogony then begin [B+02]. In
species which reproduce within a vacuole, the initial steps in
replication take place in close association with the inner membrane of
the vacuole. The transition to sporogony is marked by release of the
developing spore into the lumen of the vacuole [B+00] and the
accumulation of electron dense material near the periphery of the cell
[H+01]. Both merozonts and sporozonts show little internal
organization [H+01] (see also images from [B+00]). In at least two,
widely divergent systems, electron-dense extracellular tubules have
been observed surrounding developing spores during sporogony [B+00]
[C+02]. When the spores completely fill the host cell cytoplasm, the
cell lyses and releases the spores to the surroundings. In some
systems, the microsporidian infestation may cause the development of
xenomas. See, e.g., [MA02].
Also, for the others- I found this:
"When you dine with the devil, bring a long spoon."
Al, be nice to NiKKI..Nikki..nice talking with you...keep in touch. Guys, look at what I linked above. It will help you with your doctors appts.
Remember: To everyone I talked to; Get those doctors to call me and I will put them in touch with the doc we have and give them the protocol to follow for office visits, once we complete it at the end of January.
We would lke to talk to those docs in those states before January 15th if at all possible plus we will give them a listing on http://NETMEDVISIT.COM for free.
Please ignore the negative hateful people making comments to stand in the way of our progress.
They are afraid we will get somewhere so they lie and put out venimous BS whenever I type anything good and productive.
Please take note of thier names and who they are. Some go under a few names on this site making you think they are different people. It will be obvious to you after a while who they are.
I want to thank everyone for stepping forward and deciding to be activists in this cause and for ignoring the LOGS who make it their mission to stand in our way and do NOTHING for the cause but stand in the way and posts volumes of nonsense dis-information..
And I want to thank F&S for making all that possible.
Without his courageous words of wisdom, I don't think I would have gotten the numerous phone calls I received in the last few days. Thank you!
I feel we are finally making some progress.
Please anyone else wanting to help with this project of getting one doctor in each state, please call me.
Love to all!
During the End Times, Good will battle Evil. Where do you stand?
It was very nice speaking with you last night. I will stay in touch,
I really feel good about this I feel there is much hope, this will work. Already
today I have been making some calls to a few Docs. Thank You for the tip's!!
Talk to you soon, bye!!!
P.S. I gave your # to my dad as well!!
I read your post a couple of pages back. I'm not ignoring you dear, I'm just too exhausted to reply intelligently. I worked a 14 hour day today attempting to catch up on professional commitments that pile up any time that I get a coulple of days off. Things will get back to normal in a couple of days. I may be scarce until then.
Looks like a lot more tolerance and productive discussion happening this year.
Back in a couple of days.
Observation in the field:
En toda caso, solo dos hongos de importancia medica, Phythium insidiosum y Rhinosporidium seeberi se encuantran en el primero de ellos, aunque es possible que el alga Prototheca wickerhamii, responsable de esporadicos casos de infeccion subcutanea, termine tambien por incluirse en este grupo.
"The diagnosis of these rare infections is based largely on detection of characteristic structures observed on histopathologic examination of tissue"
http://www.pubmedcentral.nih.gov/articl ... id=1081399
Search query via google with:
Prototheca wickerhamii + synechocystis
(microcystis = synechocystis = synechococcus = prochlorococcus)
MITOCHONDRIAL GENES IN THE COLORLESS ALGA PROTOTHECA-WICKERHAMII RESEMBLE PLANT GENES IN THEIR EXONS BUT FUNGAL GENES IN THEIR INTRONS.
WOLFF, G; BURGER, G; LANG, BF; KUCK, U. 1993. MITOCHONDRIAL GENES IN THE COLORLESS ALGA PROTOTHECA-WICKERHAMII RESEMBLE PLANT GENES IN THEIR EXONS BUT FUNGAL GENES IN THEIR INTRONS. NUCLEIC ACIDS RESEARCH 21: 719-726.
A total of 29 recurring sequence motifs (30 to 200 nt long) have been found in intergenic regions. Nine different types of motifs are present, most of them arranged as tandem repeats. These motifs may be implicated in transcription, e.g. as signals for initiation, termination and/or processing. Phylogenetic analysis on the basis of the cox1 gene strongly suggested that P. wickerhamii and plant mitochondrial genomes are monophyletic. The finding of plant-specific mitochondrial genes such as orf25, orf244, orfB and rrn5 in P. wickerhamii mitochondria corroborates this idea.
http://www.mitochondrial.net/showabstra ... id=8133522
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