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repair mechanism?

Genetics as it applies to evolution, molecular biology, and medical aspects.

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repair mechanism?

Postby karkar » Fri Nov 10, 2006 10:28 pm

when the repair mechanism for DNA fails, the result is a?



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Postby canalon » Fri Nov 10, 2006 11:36 pm

The result depends on the kind of correction the repair mechanism is suppose to correct: transition, transversion, nick, and many other possibilities.
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Re: repair mechanism?

Postby sdekivit » Sat Nov 11, 2006 10:41 am

karkar wrote:when the repair mechanism for DNA fails, the result is a?


dysplasia or neoplasia
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Re: repair mechanism?

Postby druid » Sat Nov 11, 2006 12:31 pm

sdekivit wrote:
karkar wrote:when the repair mechanism for DNA fails, the result is a?


dysplasia or neoplasia

Another option is apoptosis.
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my caffeine pls

Postby honee_v » Fri Nov 17, 2006 2:30 am

ive read that caffeine (found in coffee, in some drugs, etc) is a potent inhibitor of DNA repair by binding to DNA... but, based on that study, drinking coffee would lead to significant harmful effects when a 60kg person consumes 75-100 cups of coffee (with 10g caffeine) in a short period of time..

ive brought this up coz im a terrible coffee drinker... and if too much consumption of caffeine (typically found in coffee, energy drinks, tea, chocolates and soda) can inhibit repair of DNA then chances are it cud lead to unfavorable effects like cancer (?), apoptosis, and premature aging (?)
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Postby i_r_e_d » Fri Nov 17, 2006 6:29 pm

WHOA!!!! No more red bulls for me!!! But 75-100 cups of coffee in a short period of time is a lot... depending on how short of a time it is... how short?
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Postby honee_v » Sat Nov 18, 2006 8:11 am

it wasnt specified.. but it further says that the caffeine in this amount of coffee could be fatal in humans when taken all at once...
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Postby MrMistery » Sat Nov 18, 2006 8:51 am

it could be fatal: it may give you ulcers.
now, from what i have read, caffeine does induce mutations in bacteria by inhibiting an enzyme linked in purine synthesis. however, humans posses a slightly different enzyme for purine synthesis at that stage and caffeine acts only as a mild inhibitor and at high concentration. Never have i read that it inhibits the repair mechanism for other mutations as well.
so, unless told otherwise, i will continue to drink my 5 cups of coffee a day
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Re: repair mechanism?

Postby sdekivit » Sat Nov 18, 2006 9:54 am

druid wrote:
sdekivit wrote:
karkar wrote:when the repair mechanism for DNA fails, the result is a?


dysplasia or neoplasia

Another option is apoptosis.


not in a tumor with a p53 mutation or a mutation in for example the BRCA1-gene.
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