Mutation

[biostudent84]

As much as I know, sickle cell anemia is a mutation. A person with sickle cell anemia has the tirplet GTG instead of GAG in the gene for hemoglobin. This base situation causes a valine to replace a glutamic acid in the hemoglobin. So.... Why don't we call this a mutation?

If I inherit a mutated gene from my father, then it is not a mutation in my body. The sequence of DNA that causes sickle-cell anemia can either be a mutation, or on an inherited allele.

[Jelanen]

Thats what I've been trying to say, but haven't seem to been able to put it that clear. Thanks.

-Jelanen

[MrMistery]

"Benefical and neutral mutations are transmitted to descendents"- Alberts textbook
So, when does a mutation stop being a mutation? F1? F2?

[canalon]

Thats what I've been trying to say, but haven't seem to been able to put it that clear. Thanks.

-Jelanen

OK, sorry for this misunderstanding.

But what I wanted to say is that SCA is the product of a mutation that has been succesfully selected for.
But even in the first generation, the mutation GAG->GTG is still codominant, hence not recessive! So beside this problem of the definition of the term "mutation" what I was saying still holds true.

[biostudent84]

"Benefical and neutral mutations are transmitted to descendents"- Alberts textbook
So, when does a mutation stop being a mutation? F1? F2?

Look at genetic diseases. They had to come from some mutation somewhere along the line. I think Alberts made an absolute statement...an no-no in biology. It happens though...

[victor]

Yeah..I think about the same also. Sickle cell anemia is a mutation that happen on one of the organic bases so it produces wrong protein which is Valine instead of Glutamic acid..

[victor]

I think for this sickle cell anemia case is mutation because the first condition that happen is a misreplication of organic bases then it lead to the misreplication of protein. So, this case is mutation..anyway, if this illness is inherited to the nect generation it's not called an inherited allele illness because the first problem that happened is mutation..What do you think of that?

[Poison]

when it is inherited, yes, it isn't a mutation in your body, but the starting of it is a mutation. And the books I looked name it as a mutation too.

[MrMistery]

Mine also ozge...