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Mutation

Genetics as it applies to evolution, molecular biology, and medical aspects.

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Postby biostudent84 » Thu May 12, 2005 6:49 pm

Poison wrote:As much as I know, sickle cell anemia is a mutation. A person with sickle cell anemia has the tirplet GTG instead of GAG in the gene for hemoglobin. This base situation causes a valine to replace a glutamic acid in the hemoglobin. So.... Why don't we call this a mutation? :roll:


If I inherit a mutated gene from my father, then it is not a mutation in my body. The sequence of DNA that causes sickle-cell anemia can either be a mutation, or on an inherited allele.
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Postby Jelanen » Thu May 12, 2005 6:51 pm

Thats what I've been trying to say, but haven't seem to been able to put it that clear. Thanks.

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Postby MrMistery » Thu May 12, 2005 7:37 pm

"Benefical and neutral mutations are transmitted to descendents"- Alberts textbook
So, when does a mutation stop being a mutation? F1? F2?
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Postby canalon » Thu May 12, 2005 7:39 pm

Jelanen wrote:Thats what I've been trying to say, but haven't seem to been able to put it that clear. Thanks.

-Jelanen


OK, sorry for this misunderstanding. :oops:

But what I wanted to say is that SCA is the product of a mutation that has been succesfully selected for.
But even in the first generation, the mutation GAG->GTG is still codominant, hence not recessive! So beside this problem of the definition of the term "mutation" what I was saying still holds true. 8)
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Postby biostudent84 » Thu May 12, 2005 7:58 pm

MrMistery wrote:"Benefical and neutral mutations are transmitted to descendents"- Alberts textbook
So, when does a mutation stop being a mutation? F1? F2?


Look at genetic diseases. They had to come from some mutation somewhere along the line. I think Alberts made an absolute statement...an no-no in biology. It happens though...
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S-hemoglobin..mutation?

Postby victor » Sun May 15, 2005 11:36 am

Yeah..I think about the same also. Sickle cell anemia is a mutation that happen on one of the organic bases so it produces wrong protein which is Valine instead of Glutamic acid..
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Mutation and inherited allele

Postby victor » Sun May 15, 2005 11:46 am

I think for this sickle cell anemia case is mutation because the first condition that happen is a misreplication of organic bases then it lead to the misreplication of protein. So, this case is mutation..anyway, if this illness is inherited to the nect generation it's not called an inherited allele illness because the first problem that happened is mutation..What do you think of that?
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Postby Poison » Sun May 15, 2005 2:06 pm

when it is inherited, yes, it isn't a mutation in your body, but the starting of it is a mutation. And the books I looked name it as a mutation too.
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Postby MrMistery » Sun May 15, 2005 5:48 pm

Mine also ozge...
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