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Selfish Gene query

Genetics as it applies to evolution, molecular biology, and medical aspects.

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Selfish Gene query

Postby rob3 » Tue Oct 17, 2006 10:12 pm

Hey all,

I have been going over my UCAS statement (required for university entry) and have noticed an error of words, it is too late to change now however I believe there could be a way out.
What I need to know is a specific example of a gene actively inhibiting the expression of its allele in the phenotype, and the complexities of this process, any help would be greatly appreciated,

Thanks,

rob
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Postby Ultrashogun » Sun Oct 22, 2006 3:05 pm

Like an operon with a repressor?
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Postby MrMistery » Sun Oct 22, 2006 4:10 pm

"a gene actively inhibiting the expression of it's alele"
a dominant gene over a recessive one :lol:
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Postby rob3 » Mon Oct 23, 2006 11:45 am

Thanks,
How does a dominant gene inhibit the expression of its allele?
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Postby sdekivit » Mon Oct 23, 2006 3:06 pm

rob3 wrote:Thanks,
How does a dominant gene inhibit the expression of its allele?


it's gene dosage. Normally, 50% of the gene products suffices to function ok and thus most inborn errors of metabolism are recessive (50% of the normal gene suffices for normale metabolism)
Sometimes there are feedback loops that compensate for the reduced gene dosage at the transcriptional level.

--> in some cases 50% is not enough to function as it should and then we speak of haploinsufficiency.
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Postby trent boyett » Fri Oct 27, 2006 12:45 am

For ideas involving a gene actively inhibiting the expression of its allele in the phenotype. You make acutally want to read "The selfish gene" by Richard Dawkins. It's very simplified though. Might not be what you're looking for but give it a try.

If I find my copy I'll have a scan through and find some examples.
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Postby rob3 » Fri Oct 27, 2006 8:33 am

I have read it, but I skipped some small bits out, I hadnt realised that it had any examples. Thanks.
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Postby trent boyett » Sat Oct 28, 2006 7:26 pm

What version have you got - because there's the one that came out march this year (the one I have) and then there's the classic 70's one.
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Postby sdekivit » Sat Oct 28, 2006 9:00 pm

MrMistery wrote:"a gene actively inhibiting the expression of it's alele"
a dominant gene over a recessive one :lol:


yes: the dominant negative effect --. the dominant mutated gene can inhibit the product of the normal gene.
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Postby rob3 » Sun Nov 12, 2006 3:28 pm

I have the new edition-30th anniversary copy. Thanks for all your help everyone.
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