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Rabbit Cells

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Rabbit Cells

Postby Condraz23 » Sat Oct 14, 2006 11:21 pm

Physiologically, rabbit cells and human cells are very similar. Therefore, how does the body realize that rabbit cells do not belong in the body?

Last edited by Condraz23 on Mon Jun 04, 2007 12:38 pm, edited 1 time in total.
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Postby Dr.Stein » Sun Oct 15, 2006 5:19 am

I believe that there is no identical structure of every single cell from different species, even from a species, even from an individual. For example, spermatozoon is recognized as foreign cell by immuno-competent cells because these cells never "see" spermatozoa during their education or antigen-dependent maturation.

Thus, rabbit cell, whatever it is, will be a foreign one to human body. That's why we can yield human antibodies or antisera from rabbit. If rabbit cell is recognized as self-cell, the exposure will generate immuo-tolerance, we cannot yield anything.

The recognition process can be done by pattern-recognition mechanism or protein-surface identification by MHC.
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