Login

Join for Free!
118322 members


Programmed cell death in E. coli

Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.

Moderator: BioTeam

Programmed cell death in E. coli

Postby ac83 » Sat May 07, 2005 3:47 am

Hi people,

I have to do a presentation on a paper which talks about using a genetially engineered m13 phage that will cause programmed cell death on e.coli cells. This paper talks about using methods like this as a possible alternative treatment of bacterial infections. What I need to know more about is programmed cell death in E.coli. Anything about it, if anyone knows anything it would be appreciated.

thanks
ac83
Garter
Garter
 
Posts: 10
Joined: Sat May 07, 2005 3:38 am
Location: Sydney

Postby telomerase » Sat May 07, 2005 6:47 am

being unicellular with a circular genome (no chromosome-end problem), I always wondered... why would a bacteria kill itself???

it has been documented that bacteria actually does! in response to infection, and to maintantain colonial organisation.

also in the time of starvation, a unicellular organism would kill itself to provide nutrients to neighbouring starving cells... how selfless :?

anyways,

here is a useful paper

Yarmolinsky, 1995, Programmed cell death in bacterial population, Science 267: 836-837

I would be targetting E.coli-infected cells rather than E.coli itself... since apoptotic pathways in eukaryotic cells are (shockingly) better understood... that is if you are using your virus for therapeutic reasons.

good luck
telomerase
Garter
Garter
 
Posts: 5
Joined: Fri Apr 22, 2005 1:04 pm


Return to Molecular Biology

Who is online

Users browsing this forum: No registered users and 0 guests