Human Anatomy, Physiology, and Medicine. Anything human!
Tam Tam, south, anyone?
Can you make sense of this? about the actin?
Fibrosis occurs in multiple organs and tissues ...and is characterized by the accumulation of connective tissue (myofibroblasts and misfolded a-smooth muscle actin). ...Although fibrosis severely affects the functioning of organ or tissue and is often life-threatening, no effective therapy is currently available to attenuate the process."
pdf - TNO Pharma - part of the Netherlands Organization for Applied Scientific Research
Cell Biology of Filamentous Influenza Virus (5/6/2002)
"...spherical virus production predominates in fibroblasts and non-polarized epithelial cell lines, filamentous virus production requires a polarized epithelial cell type ...a viral component may be interacting with the actin cytoskeletal network to promote filamentous particle formation. Thus, filamentous influenza virus formation requires the interaction of viral specific components with host cell components, presumably actin or actin-associated proteins."
HOPE YOU DON't MIND TAM TAM if I throw some more clues out there!
HeLa cell adherence, actin aggregation, and invasion by nonenteropathogenic Escherichia coli possessing the eae gene. Infect Immun. 1991 Nov;59(11):3924-9. Cantey JR, Moseley SL. Veterans Affairs Medical Center, Charleston, South Carolina 29403. PMID: 1682254
http://www.pubmedcentral.nih.gov/articl ... id=1682254
* HEp-2 cell adherence, actin aggregation, and intimin types of attaching and effacing Escherichia coli strains isolated from healthy infants in Germany and Australia. Infect Immun. 2003 Jul;71(7):3995-4002. Beutin L, Marches O, Bettelheim KA, Gleier K, Zimmermann S, Schmidt H, Oswald E. Division of Emerging Bacterial Pathogens, Department of Biological Safety, Robert Koch Institute, 13353 Berlin, Germany. BeutinL@rki.de PMID: 12819087
http://iai.asm.org/cgi/content/full/71/ ... d=12819087
* Actin control over microtubules suggested by DISTORTED2 encoding the Arabidopsis ARPC2 subunit homolog. Plant Cell Physiol. 2004 Jul;45(7):813-22. Saedler R, Mathur N, Srinivas BP, Kernebeck B, Hulskamp M, Mathur J. Botanical Institute III, University of Koln, Gyrhofstrasse 13, D-50931 Koln, Germany. PMID: 15295064
PROPAGANDA OR REAL? ANYONE?
More on that page......
Note timelines of importance.
Detection of Kaposi's sarcoma(KS)-associated herpesvirus-like DNA sequence(KSHV) in vascular lesions: A reliable diagnostic marker for KS. Am. J. Clin. Pathol. 105:360~363,1996. Jin, Y.T., S.T. Tsai., J.J. Yan., J.H. Hsiao., Y.Y. Lee. and I.J. Su.
1978 - Actin filaments in paramyxovirus-infected human fibroblasts studied by indirect immunofluorescence. PMID: 356824
1983 - Fate of microfilaments in vero cells infected with measles virus and herpes simplex virus type 1. PMID: 6343843
1985 - Interaction of frog virus 3 with the cytomatrix. III. Role of microfilaments in virus release. PMID: 4060576
1986 - Use of indirect immunofluorescence to show changes in liver actin microfilament staining in inbred mice strains exposed to the mycotoxin sporidesmin. PMID: 3526071
1986 - HERPES - Involvement of actin-containing microfilaments in HSV-induced cytopathology and the influence of inhibitors of glycosylation. PMID: 3022680
1987 - Distribution by immunofluorescence of viral products and actin-containing cytoskeletal filaments in rubella virus-infected cells. PMID: 3545151
1988 - Changes in cellular microfilaments in viral infection. PMID: 2854678
1989 - Aggregation of membrane-associated actin filaments following localized adherence of enteropathogenic Escherichia coli to HeLa cells. PMID: 2691516
1989 - Opposing microtubule- and actin-dependent forces in the development and maintenance of structural polarity in retinal photoreceptors. PMID: 2642427
1980 - Accumulation of actin microfilaments in adult rat hepatocytes cultured on collagen gel/nylon mesh. PMID: 6893678
1990 - Actin filament nucleation by the bacterial pathogen, Listeria monocytogenes. PMID: 2125302
1990 - Actin gene expression in murine erythroleukemia cells treated with cytochalasin D. PMID: 2347376
1990 - The role of microfilaments and microtubules in apical growth and dimorphism of Candida albicans. PMID: 2200842
1991 - Requirement of microfilaments in sorting of actin messenger RNA. PMID: 1891715
1991 - Sequential rearrangement and nuclear polymerization of actin in baculovirus-infected Spodoptera frugiperda cells.
1993 - Directional actin polymerization associated with spotted fever group Rickettsia infection of Vero cells. PMID: 8478082
1993 - Actin microfilaments dynamics in African green monkey renal cell line (Vero) during cultivation. PMID: 8186459
1993 - Dissociation of actin microfilament organization from acquisition and maintenance of elongated shape of human dermal fibroblasts in three-dimensional collagen gel. PMID: 8309424
1994 - Characterization of a monoclonal antibody prepared against plant actin. PMID: 7859296
1994 - Effects of thymosin beta 4 and thymosin beta 10 on actin structures in living cells. PMID: 8194107
1994 - Concentration-dependent effects of cytochalasin D on tight junctions and actin filaments in MDCK epithelial cells. PMID: 8006058
1995 - Myosin-actin interaction plays an important role in human immunodeficiency virus type 1 release from host cells. PMID: 7892219
1995 - Proteolysis of p6.9 induced by cytochalasin D in Autographa californica M nuclear polyhedrosis virus-infected cells.PMID: 7871717
1996 - HIV-1 Gag protein associates with F-actin present in microfilaments. PMID: 8661406
1996 - Plant and animal profilins are functionally equivalent and stabilize microfilaments in living animal cells. PMID: 8834793
1996 - Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite. PMID: 8601316
1997 - Microtubule-associated protein 2c reorganizes both microtubules and microfilaments into distinct cytological structures in an actin-binding protein-280-deficient melanoma cell line. PMID: 9049250
1997 - Pasteurella multocida enters polarized epithelial cells by interacting with host F-actin. PMID: 9100334
1997 - Both microtubules and actin filaments are required for efficient postendocytotic traffic of the polymeric immunoglobulin receptor in polarized Madin-Darby canine kidney cells. PMID: 9045707
1998 - Involvement of actin microfilaments in the replication of human parainfluenza virus type 3. PMID: 9525582
1998 - Role of cellular actin in the gene expression and morphogenesis of human respiratory syncytial virus. PMID: 9875324
1998 - Disruption of actin microfilaments by cytochalasin D leads to activation of p53. PMID: 9688570
1998 - Cytochalasin D alters kinetics of Ca2+ transient in rat ventricular cardiomyocytes: an effect of altered actin cytoskeleton? PMID: 9737950
1998 - Actin binding and nucleation by Autographa california M nucleopolyhedrovirus. PMID: 9527926
1999 - Involvement of actin microfilaments in the transcription/replication of human parainfluenza virus type 3: possible role of actin in other viruses. PMID: 10523790
1999 - Organized F-actin is essential for normal trichome morphogenesis in Arabidopsis. PMID: 10590162
1999 - Actinobacillus actinomycetemcomitans may utilize either actin-dependent or actin-independent mechanisms of invasion. PMID: 10495707
1999 - The role of actin microfilaments in the down-regulation of the degranulation response in RBL-2H3 mast cells. PMID: 9973500
1999 - Distribution of cytoskeletal structures and organelles of the host cell during evolution of the intracellular parasitism by Trypanosoma cruzi. PMID: 10626001
1999 - Role of actin filaments in the hatching process of mouse blastocyst. PMID: 10418105
1999 - "HIV-1 NCp7 can bind F-actin directly and ...interaction between HIV-1 Gag and the actin cytoskeleton through the NC domain may play an important role in HIV-1 assembly and/or other steps of the viral life cycle." PMID: 10074138
2000 - Filamentous actin is required for lepidopteran nucleopolyhedrovirus progeny production. PMID: 10859396
2000 - Enhancement of herpes simplex virus-induced polykaryocyte formation by 12-O-tetradecanoyl phorbol 13-acetate: association with the reorganization of actin filaments and cell motility. PMID: 11044806
2001 - "A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and bacterial internalization." PMID:11136447
2001 - Hantavirus nucleocapsid protein is expressed as a membrane-associated protein in the perinuclear region. PMID: 11160679
2001 - Actin microfilaments facilitate the retrograde transport from the Golgi complex to the endoplasmic reticulum in mammalian cells. PMID: 11576448
2001 - Actin cytoskeleton role in the structural response of epithelial (MDCK) cells to low extracellular Ca2+. PMID: 11763195
2002 - Participation of host cell actin filaments during interaction of trypomastigote forms of Trypanosoma cruzi with host cells. PMID: 12207050
2002 - A functional link between the actin cytoskeleton and lipid rafts during budding of filamentous influenza virions.
2002 - Cytoskeletal changes during poliovirus infection in an intestinal cell line. PMID: 12138662
2002 - Microinjected anti-actin antibodies decrease gap junctional intercellular commmunication in cultured astrocytes. PMID: 12460650
2002 - Chlamydia trachomatis induces remodeling of the actin cytoskeleton during attachment and entry into HeLa cells.
2003 - Actin filaments participate in West Nile (Sarafend) virus maturation process. PMID: 12966555
***2003 - Interaction of HLA-DR with actin microfilaments. PMID: 12590977***
2003 - Effects of cytochalasin D on the actin cytoskeleton: association of neoformed actin aggregates with proteins involved in signaling and endocytosis. PMID: 12827288
2003 - Disruption of F-actin stimulates hypertonic activation of the BGT1 transporter in MDCK cells. PMID: 12527556
2004 - Role of actin microfilaments in canine distemper virus replication in vero cells. PMID: 15133271
2004 - Role of actin filaments in targeting of Crimean Congo hemorrhagic fever virus nucleocapsid protein to perinuclear regions of mammalian cells. PMID: 14635015
2004 - Actin filaments play an essential role for transport of nascent HIV-1 proteins in host cells. PMID: 15020258
2004 - Role of cytoskeleton components in measles virus replication. PMID: 15098105
ACTIN - IN ALL LIVING CYTOSKELETONS - MEMBRANES (INSIDE OUTSIDE)
1990 - Microinjection of covalently cross-linked actin oligomers causes disruption of existing actin filament architecture in PtK2 cells. PMID: 2277094
1992 - Distribution of F-actin during mouse facial morphogenesis and its perturbation with cytochalasin D using whole embryo culture. PMID: 1517392
1994 - Differences in the G/total actin ratio and microfilament stability between normal and malignant human keratinocytes.PMID: 7834816
1998 - Actin microfilaments are essential for the cytological positioning and morphology of the Golgi complex. PMID: 9650778
1999 - Expression and characterization of Cys374 mutated human beta-actin in two different mammalian cell lines: impaired microfilament organization and stability. PMID: 10428484
2000 - Cytochalasin D reduces Ca2+ sensitivity and maximum tension via interactions with myofilaments in skinned rat cardiac myocytes. PMID: 11101650
2000 - Optimal development of Chlamydophila psittaci in L929 fibroblast and BGM epithelial cells requires the participation of microfilaments and microtubule-motor proteins. PMID: 10839969
2002 - Endoplasmic reticulum calcium release is modulated by actin polymerization. PMID: 12358800
2000 - Actin filament disruption inhibits L-type Ca(2+) channel current in cultured vascular smooth muscle cells. PMID: 10913014
2000 - Changes in actin network during calcium-induced exocytosis in permeabilized GH3 cells: calcium directly regulates F-actin disassembly. PMID: 10974661
2000 - Actin depolymerization and polymerization are required during apoptosis in endothelial cells. PMID: 10867649
2000 - Specific types of prosomes distribute differentially between intermediate and actin filaments in epithelial, fibroblastic and muscle cells. PMID: 10928458
2000 - Effects of cross-linked profilin:beta/gamma-actin on the dynamics of the microfilament system in cultured cells. PMID: 10739658
2001 - Actin filament nucleation by endosomes, lysosomes and secretory vesicles. PMID: 11163138
2001 - Actin filaments and myosin I alpha cooperate with microtubules for the movement of lysosomes. PMID: 11739797
1998 - Stable expression of nucleocapsid proteins of Puumala and Hantaan virus in mammalian cells. PMID: 9857992
1997 - Modification of cytoskeleton and prosome networks in relation to protein synthesis in influenza A virus-infected LLC-MK2 cells. PMID: 9381792
2004 - Tula hantavirus L protein is a 250 kDa perinuclear membrane-associated protein. PMID: 15105534
1994 - The role of microfilaments and microtubules during pH-regulated morphological transition in Candida albicans. PMID: 8180693
2002 - Involvement of SipA in modulating actin dynamics during Salmonella invasion into cultured epithelial cells. PMID: 2116966
1999 - Induction of an acrosomal process in Toxoplasma gondii: visualization of actin filaments in a protozoan parasite. PMID: 10430901
2003 - A role for glycoprotein C in pseudorabies virus entry that is independent of virus attachment to heparan sulfate and which involves the actin cytoskeleton. PMID: 12667810
2002 - Actin mediates secretory immunoglobulin A transport: effect of ethanol. PMID: 12356147
1987 - Effects of microfilament disrupters on microfilament distribution and morphology in maize root cells. PMID: 3623996
2001 - Actin polymerization is essential for pollen tube growth. PMID: 11514633
Public health policies blame the victims, saying FMD and its various secondary effects are either genetic or self-inflicted. Laws are used to remove the afflicted from society, and new legislation is planned to offload responsibility for the disabled and dysfunctional. Other plans are in development to take away victims’ civil rights and rights of citizenship in later stages of disease progression, including the right to vote.
Ie., See: http://www.atsnn.com/story/90609.html
In short: FMD is epidemic but ordinary Americans cannot access early diagnosis or preventive medical treatments; available methods are not being implemented to stop FMD’s spread and transmission, or to remove contaminants that cause disease progression. Americans are left with no way out, unable to avoid infection or exposure to contaminants that promote and speed disease progression, and unable to find treatment. Many will become physically disabled or mentally dysfunctional long before retirement age – but will not have access to funds or other supports. Many, likely the majority, will lose their voting rights along with their ability to work, think and love.
FMD was acknowledged officially as a new but rare disease in 1938. Today, most Americans are infected by adulthood. FMD usually incubates silently in the body for decades before striking. It is progressive, degenerative and incurable. It is always eventually fatal, and is seldom diagnosed and treated before it becomes life threatening. Early diagnosis and treatment are not covered by insurance. In order to survive socially and professionally without medical help, victims are forced to try and hide their symptoms from the world and often, themselves.
65% of reported FMD cases in the USA are diagnosed in autopsy, and the disease is found in almost 100% of reported deaths.
from Source: http://www.abovetopsecret.com/forum/thread112220/pg1
Awwwwwwww People.........Look at the reasoning for not being treated!
Look at the year this began.....FMD 1938, the same year DOP was established the Ekbom Theory.
We have here...................This is it, folks now get the specifics.
I think someone has already done the homework.
Actin and the fibers are fibrils and filaments, the EU keyed me off to this.
and there is more, but, there are also many places working on this and are documenting this.
Please do read and you will find almost everything we have discussed on LB and here.
MD is pretty much explained here as well, as is any 0f the neuro diseases.
Will come up with list of those who are aware and how they can help.
We had it all in bits and pieces folks.
Now, we know our numbers and those who care are out there. We will find them.
And yes C3, C4, you name it is there, and certain ones are susceptible and X-linked recessive is involved.
Hence, the POLIO, AIDS, LYMES, ALZHEIMERS, MORGELLONS and I would add Muscular Dystrophy. Been lookin a long time folks, but, this was beyond our control even before we were born.
You scientist, that are brave, please do come out and let us know who is trustworthy.
Trustworthy? why that's anyone that does not work for the government Sky. Great post you did there. Interesting too. Hey, what's your take on the "You Know" blood disease , God I can't even say it......? Just curious, if you have looked at it anymore.....I turned it off for a day. But it's Monday early morning so....haha....I can talk about it....Seriously, I have my Doctors apn't tomorrow since I did not make it Friday.
Dear 1arrow, Hi, I did not forget to get back with you- It was strange. Like a week after you Posted here and I said I was interested in learning more about the treatments, I read an article that said the exact opposite.
So it thru me off, hince, I had forgotten about it. You said:
There have been doctors curing HIV/AIDS complex with Ozone therapy. One doctor had 318 documented cases. They (FEDs) destroyed his clinic an put him in jail.
Well, that's comforting.... sign me up.....Can you give a breif rundown on how much it cost, how many sessions, how long are the sessions.....(is this like a hiperbaric chamber?) or totally different?
Administered by a physician or a nail tech? haha I'm just joking....hell, the nail tech would probably be better. Lastly, why the the stupid-arse gov't bust this person.....I mean why? Were they po'd that the population was not being knocked off soon enough.....?
I just do not get it....I do not get how in the hell this President has gotten away with the stupid invasive , breaking the law crapola that he has?
I mean they can break into our homes and not even tell us until after the fact.....Thanks to Bushy.......
But Mr Bill, Smokews a cigar in the oval office and all hell breaks loose....Impeach him b/c of sex with someone besides that that that....Hillery woman? Like that's any of our business.....but Lord, let George and his patriot acts of insanity come into our home and read what we write on the internet and it's okay......shhhhhh.........well I hate em!
This is the worst president that we will ever witness I do believe. Sorry.....to get off the subject.....can you please tell me why? What was the purpose of the raid? Did they find what they were after?
Oxford and it's affiliates:
the next step?
Fundamental control over supra-molecular self-assembly for organization of matter on the nano-scale is a major objective of nanoscience and nanotechnology. ‘RNA tectonics’ is the design of modular RNA units, called tectoRNAs, that can be programmed to self-assemble into novel nano- and meso-scopic architectures of desired size and shape. We report the three-dimensional design of tectoRNAs incorporating modular 4-way junction (4WJ) motifs, hairpin loops and their cognate loop–receptors to create extended, programmable interaction interfaces. Specific and directional RNA–RNA interactions at these interfaces enable conformational, topological and orientational control of tectoRNA self-assembly. The interacting motifs are precisely positioned within the helical arms of the 4WJ to program assembly from only one helical stacking conformation of the 4WJ. TectoRNAs programmed to assemble with orientational compensation produce micrometer-scale RNA filaments through supra-molecular equilibrium polymerization. As visualized by transmission electron microscopy, these RNA filaments resemble actin filaments from the protein world. This work emphasizes the potential of RNA as a scaffold for designing and engineering new controllable biomaterials mimicking modern cytoskeletal proteins.
source: http://nar.oxfordjournals.org/cgi/conte ... /34/5/1381
Just one, there are more.......
HOPE YOU DON't MIND TAM TAM if I throw some more clues out there!
Is this a game being played? What does HOPE YOU DONT MIND....CLUES?????
This is the reason I have stopped payng attention to this site.
During the End Times, Good will battle Evil. Where do you stand?
I do not appreciate the mockery. If you would just read. Maybe you would learn something.
I was being friendly, that is all.
Randy, there is so much involved in this, you do not have a clue.
How in the heck do you think any type of mutation occurred that would cause any disease?
Mutations DNA to DNA. Do you get it?
Called transposons. Get it?
Do you ever think?
Please don't come on here, if your purpose is to mock.
I am looking for this and will till I die.
When the AMA turned on us dear, they turned on all of us. Until you recognize the history and what has happened, you will never have a clue as to how any DNA change using bacterias/viruses will affect human genes and will only cause adaptation and natural selection to happen due to mutation.
So America is in for new diseases because of the what has happened in the past. When the first genes were altered, proteins rearranged, that is when this all started, whether bioweapon or just messing in the lab.
But, a scheme for causing human adaptation and natural selection or gene selection is in place, and if you cannot recognize that, then you really need to educate yourself.
Also dermatopathologists need to come back into Dermatology:
Ever heard of Dr. Weems?
CUTANEOUS ADULT MYOFIBROMA
Myofibromatosis was first described in infants and those lesions were often multiple or generalized. Subsequently, solitary lesions having this type of pathology have been described in adults and have been the subject of a moderately large series ref 1. Many of the solitary myofibromas from adults have a biphasic pattern consisting of fibromyxoid areas containing cells resembling smooth muscle cells plus more cellular areas within which there may be vascular channels resembling those found in pericytomas. The background stroma in the fibromyxoid areas is sometimes hyalinized. The architecture is often lobulated. Other cellular constituents and patterns have led to the conclusion that myofibromas may be related to other tumors having perivascular myoid differentiation ref 2 .
The current case (plus a photomicrograph from another adult case) has the biphasic pattern mentioned above. The myxoid component in the connective tissue was not prominent in the initial sections but is prominent in deeper sections stained another day. The cellular areas were not seen in the deeper sections. Therefore differences in sampling and staining could lead to varying interpretations regarding the pathology of this lesion.
This fragmented specimen was obtained from the dermis and subcutis of the cheek of a 26 year old female. The mass was solitary.
Maybe look at the pictures, might help.
Also, there are problems with Actin:
http://www.amjdermatopathology.com/pt/r ... 45!8091!-1
These are the people we need to examine our lesions.
This is you twos Mediateor!!! Hey stop it; we all need each other now.
Randy, You know I love you so know that when i say this, I'm not doing it in a harsh or malicious way, but I have to agree with Skytroll there.
Think of it this way, maybe, just maybe she was being facetious????
But I know you are smart Randy, and that 's why I did not get what you said to Sky.....This lady has put a plethora of solid, cold -hard facts out there. I just could not even grasp the thought of you , nor anyone else bringing down her great postings to the sophemoric level by saying something to how she addressed TamTam? I mean, wtf and whotf even cares about that.
Hell, maybe your are a diversion tactic as well as the many others ? I'm
Not being mean either- I'm really not. I know that you and Skytroll spoke on the phone before a couple of months back....How do I know? Because she wrote me. You know what she said Randy? That you were a very smart girl! Nothing but good came out of Skytrolls mouth.
Like I said, I'm not siding on anyone's side here,....I don't have time to do that .
Anyway, let's please move on......and
Last edited by London on Tue Jul 11, 2006 7:54 am, edited 1 time in total.
My mother has morgellons and I have been feeling so scared. I am scared for the other members in my family also who are staying (renting the other side of her house) and share her kitchen space. 3 of whom are children. I am the only child (I am 43 years old) of my moms who believes her. She has been desperately researching this and is taking cipro and I don't know if she has heard about the aloe vera. She talks a lot about Sulfer being an alleviator to this problem. She uses sulfer soap and other products along with her medicines. Sulfer lotion helps the itching.
I am devastated. If you don't have lyme are you safe from this disease? Or does no one know. In California I read that Diane Feinstein is aware of this disease and that anyone with it is told to write to her about it.
Can you tell me if you know if anything else that can help?
Thank you so much.
I am sorry to hear that your Mother is suffering. Thank God she has such an understanding daughter such as your self!
As far as being believed, I have come to realize that not everyone can handle the truth so the denial you see becomes a coping mechanism. People are sometimes incapable of living in reality.
Please read everything you can on Dr. Schwartz’s treatment for this condition. So far I have found his protocol to be the most helpful thing we have as of yet in the way of medications. You may wish to contact him through this website.
So far there is no scientifically verifiable evidence linking the Fiber disease to Lyme disease in anyway what so ever. This condition has been speculated that it can be vectored by an insect (although not the only way to become infected) and I believe this.
Hang in there because it does get easier to deal with down the road. Once you figure out how a body is affected by this and how to treat it you and your Mom will feel better. We do have the knowledge to be able to reduce our symptoms.
Dermatech solutions have some products that have helped a lot of people so far and they have been very kind to us sufferers. You may wish call them as I have heard that they are very helpful on the phone.
http://shop.qbased.com/index.asp?PageAc ... ategory=12
Please contact the CDC, let them know you need some help. You may also wish to contact your Health Department, they are not as bad as what you may hear and can offer assistance if not actual treatment. You can contact Senator Feinstein if you like but I think you have a much better chance of asking Senator Boxer for help, just my opinion.
As far as being able to protect other innocent people, as sad as it is, there is nothing we can do about this for now but watch it happen. This is a very important issue that you may wish to address to the CDC when you write to them.
You may also find some support on Lymebusters but be very cautious in what information you decide to give and take on any site.
Good luck to you and your family, my prayers are with you.
Please keep us updated.
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