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Contraceptive pills

Human Anatomy, Physiology, and Medicine. Anything human!

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Contraceptive pills

Postby zyphanx » Sat Apr 01, 2006 6:31 am

Type I Diabetes usually treat with injections of insulin instead of pills, as insulin may be digested in the guts if taken orally

From what I know, the thing that makes contraceptive pill works is progesterone, which is also a kind of hormone.

then how come progesterone is not being digested in the guts and still able to carry out it functions?
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Postby LilKim » Sun Apr 02, 2006 1:47 am

this is a guess (and hopefully someone will correct me if i'm wrong)

Insulin is a peptide hormone... and enzymes (in the gut) digest peptides and sugars. However, progesterone is a steroid hormone and because of the molecular composition (it's not a protein) the enzymes in the gut cannon digest/degrade it.

Therefore, the steriod (progesterone) is "absorbed" into the bloodstream as an intact molecule ... whereas insulun would be broken and absorbed as amino acids (broken-down peptides) if ingested orally.
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Postby MrMistery » Sun Apr 02, 2006 7:25 pm

Absolutely correct. Just one thing to add. Progesterone gets absorbed in the stomach, unlike mostly everything else that is absorbed in the intestine. Because it's lipid soluble.
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Postby PERO » Tue Apr 04, 2006 9:29 am

I agree tottaly with Lilkim.
and like her way of thinking. :D
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Postby LilKim » Fri Apr 07, 2006 4:02 am

Awww.. thanks Pero! :-)
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Postby MrMistery » Fri Apr 07, 2006 7:24 pm

Did i say i didn't agree with LilKim? It's just that it needs to get absorbed in the stomach, as pancreatic juice contains an enzyme that breaks down progesteron to cholesterol.
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