Login

Join for Free!
116831 members


Mutation Question

Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.

Moderator: BioTeam

Mutation Question

Postby aquashark » Sun Apr 03, 2005 4:56 pm

Which type of genetic mutation is most dangerous and why, point mutation, insertion mutation, and deletion mutation? Thanks!
aquashark
Garter
Garter
 
Posts: 5
Joined: Sat Mar 19, 2005 4:03 pm

Postby thank.darwin » Sun Apr 03, 2005 10:44 pm

I would say both insertion mutation and deletion mutation - DNA is read in triplets so everything would get moved forward or backwards... Here is an example...

THE OLD DOG RAN AND THE FOX DID TOO

if you add in a random S look what happens...

THE OLD SDO GRA NAN DTH EFO XDI DTO O

or a deletion...

THE OLD OGR ANA NDT HEF OXD IDT OO

Hope that helps :D
No amount of experimentation can ever prove me right; a single experiment can prove me wrong.
-Albert Einstein
User avatar
thank.darwin
Inland Taipan
Inland Taipan
 
Posts: 347
Joined: Thu Jan 27, 2005 7:39 pm
Location: Vancouver, Canada

Postby Poison » Mon Apr 04, 2005 6:53 am

I don't think you can say point mutations are less important than others.
The example about the sentence is good but think that some point mutations may not be tolerated too.
I may be wrong, but if anyone has more proof (not like a sentence but a proof from life) about insertion mutation and deletion mutation are more dangerous than point mutation, I would be very happy to know that. :)
It matters not how strait the gate
How charged with punishment the scroll
I am the Master of my fate
I am the Captain of my soul.
User avatar
Poison
Inland Taipan
Inland Taipan
 
Posts: 2322
Joined: Sun Jan 02, 2005 12:44 pm
Location: Turkey


Postby biostudent84 » Mon Apr 04, 2005 11:40 am

thank.darwin wrote:I would say both insertion mutation and deletion mutation - DNA is read in triplets so everything would get moved forward or backwards... Here is an example...

THE OLD DOG RAN AND THE FOX DID TOO

if you add in a random S look what happens...

THE OLD SDO GRA NAN DTH EFO XDI DTO O

or a deletion...

THE OLD OGR ANA NDT HEF OXD IDT OO

Hope that helps :D


I think the best way to explain it, Poison is to use the sentence example first...

Our normal genome:
THE OLD DOG RAN AND THE FOX DID TOO

You've seen what happens when there is an addition or deletion. But if there is simple substitution...watch:

THE LLD DOG RAN AND THE FOX DID TOO

See? Only one word, or in the case of a genome--codon--was rendered incorrect. In an addition or deletion, we have what is called a frame shift mutation which changes the entire way DNA is read. With a substitution, only one protein in the sequence will be potentially incorrect.

And since an average of three codons code for every amino acid, there is a chance that, with a substitution, a mutation might not even affect the protein to be made.
User avatar
biostudent84
Site Admin
Site Admin
 
Posts: 974
Joined: Thu Nov 11, 2004 6:00 am
Location: Farmville, VA

Postby aquashark » Mon Apr 04, 2005 3:39 pm

Thanks everybody for helping!
aquashark
Garter
Garter
 
Posts: 5
Joined: Sat Mar 19, 2005 4:03 pm

Postby Poison » Mon Apr 04, 2005 3:58 pm

OK. Now I think you are right. but can you give me an example from real life? Just wondering if there is a proper example for this. :roll:
It matters not how strait the gate
How charged with punishment the scroll
I am the Master of my fate
I am the Captain of my soul.
User avatar
Poison
Inland Taipan
Inland Taipan
 
Posts: 2322
Joined: Sun Jan 02, 2005 12:44 pm
Location: Turkey

Postby biostudent84 » Mon Apr 04, 2005 4:03 pm

Yes there is, but I'm in class right now...I'll type one out as soon as I get out. We're going over this in Genetics 301 now.
User avatar
biostudent84
Site Admin
Site Admin
 
Posts: 974
Joined: Thu Nov 11, 2004 6:00 am
Location: Farmville, VA

Postby Poison » Tue Apr 05, 2005 3:51 pm

OK. Thanks. looking forward for a reply from you... :)
It matters not how strait the gate
How charged with punishment the scroll
I am the Master of my fate
I am the Captain of my soul.
User avatar
Poison
Inland Taipan
Inland Taipan
 
Posts: 2322
Joined: Sun Jan 02, 2005 12:44 pm
Location: Turkey


Return to Molecular Biology

Who is online

Users browsing this forum: No registered users and 2 guests

cron