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Hey friends i have a doubt on the agglutination of blood during transfusion.
Suppose blood type O is given to a person whose blood group is A.
Blood type O has two type of antibodies "anti-a" and "anti-b"
Blood type A has antigen A and antibody "anti-b"
We know that anti-b of blood type A will not react with blood type O as it does not have any antigen.
But my doubt is Will the antibody "anti-a" of type O blood will react with the antigen A of type A blood ?
Please give reason
First, you must understand the concept, which is "antigen:antibody reaction", like this:
- antigen A + anti-a = agglutination
- antigen B + anti-b = agglutination
Anti-b of blood A will not react with blood O because blood O does not contain antigen B.
- anti-b + anti-a = no agglutination
- anti-b + anti-b = no agglutination
- anti-a + anti-a = no agglutination
Anti-a of blood O will react with blood A because blood A contains antigen A.
Similarly blood AB contains no antibody but has both antigen A & B.
If blood A is given to the person whose blood is type AB then the "anti-b" of blood A will react with the antigen B of the blood AB and cause agglutination. Is it correct?
Then Why blood AB is called universal recepient?
Please clear my doubts.
Group O: No antigen on the blood cell, no agglutination because neither antiA nor antiB react with it. So it can be given to anyone (provided Rh groups and minor groups are not a problem)
Group AB: The carrier have neither antiA nor antiB (that woud cause agglutination in their blood) so whatever blood is given it won't agglutinate. Provided the same caveat as above is true.
Science has proof without any certainty. Creationists have certainty without
any proof. (Ashley Montague)
what they are asking patrick, and what i still have not figured out is:
If you give O blood to a person who has A blood type, why don't the antiA antibodies in the donor blood react with the A antigenes on the recipient's blood cells?
Similar with AB,but the other way around..
You should know that now there is NO universal donor and universal recipient anymore. It is old term that we decided not to use it anymore. Blood transfusion should be considered from similar blood type, in which the one comes from relatives is a high priority before we take from the bank.
i know that. i read it in my book. So what you are saying is there is some aglutination taking place?
I can't understand the above statement. Please make it clear.
From your post I came to the conclusion that blood transfusion can occur from the same blood type to the another.
But in my A&P book (Author Guyton & Hall- you may know ) in the chapter it is clearly written that O is the universal donor and AB is universal recepient.
And in the board exams also we write this concept.
In the past, type O Blood was given to virtually anyone except those with what was termed 'rare' Blood. Donors of Blood group O were always referred to as 'universal donors.' Today, because of new research and a better understanding of the complex issues regarding immune reaction related to incompatible donor Blood cells, type O Blood is no longer automatically seen as being suitable in most every case.
In AB case, say the one with type AB Blood is transfused with type A Blood. We know that on type A Blood there is antigen A + anti-B. This anti will clump antigen B of the type AB blood. Also, when the one with type AB Blood is transfused with type B Blood. We know that on type B Blood there is antigen B + anti-A. This anti will clump antigen A of the type AB blood. There is an agglutination reaction less or more...
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