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tamoxifen

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tamoxifen

Postby fran008 » Mon Mar 06, 2006 5:29 pm

Considering that conception must be preceded by development of ova followed by ovulation, can anyone suggest why tamoxifen 'enhanced the odds of conception in subfertile women' as says the article from Scientific American of October 1998?
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Postby Dr.Stein » Wed Mar 08, 2006 8:38 am

Tamoxifen is anti-estrogen. Applying anti-estrogen will affect the HPG axis by negative feedback, which means affect the gonadotropin (LH, FSH) release from pituitary.
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Postby fran008 » Wed Mar 08, 2006 10:15 pm

What does HPG stand for?
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Postby Dr.Stein » Thu Mar 09, 2006 5:29 am

HPG axis = Hypothalamus-Pituitary-Gonad axis ;)
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