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ADD'P to ADP

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ADD'P to ADP

Postby 2810712 » Thu Feb 23, 2006 3:11 am

the energy obtained from the 2nd and 3rd bond of ATP is equal. So why ATP is involved in biology rather that ADP... is ADP production is harder?
IN biology one can ask why to everything but explanations are rarely seen in regular college texts. This is why people call biology semiscience.
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Postby alextemplet » Thu Feb 23, 2006 4:42 am

Actually, I believe biology's explanations are found in chemistry, whose explanations are found in physics, which seeks to explain all matter, living and non-living.

Personally, I don't know the answer, but I'm sure it has to do with chemistry.
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Postby MrMistery » Thu Feb 23, 2006 7:39 pm

Well from what i know, in a hidrophobic environemnt the reaction ADP + Pi <--> ATP is reverseble, a state of chemical equilibrium. All an enzyme does is put the ADP and Pi into a hidrophobic pocket and it makes ATP. Why not ADP and AMP? Hmm... In a hidrophobic environment the reaction between ADP and AMP +Pi is not equilibrium, so i'm guessing it would have been a harder way to use it. Plus, the cyclic form of AMP and GMP evolved as secondary messagers.
Maybe not a full answer but it's all i can come up with...
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Postby 2810712 » Fri Feb 24, 2006 1:56 am

but is any disturbing interaction bet. cyclic and non-cyclic MPs possible there...and i didn't get why u said in hydrophobic environment the AMP+P <--->ADP isnot in equilibrium...bec. most of cytosol are hydrophilic... so did u mean hydrophilic.
ANd they aren't in equilibrium means enzymes won't be able to give us one of those... so...




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Postby MrMistery » Fri Feb 24, 2006 6:34 pm

No i meant hydrophobic. All an ATP synthase does is place the ADP and Pi in a hidrophobic pocket. So, it is easy easier to obtain ATP from ADP rather than ADP from AMP, since for the latter you would need some other kind of mechanism. It's easier to do it this way. My opinion, of course...
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Postby 2810712 » Sun Feb 26, 2006 1:06 pm

thanks for that...where did u get that smaty?
One doubt can an enzyme catalyze a reaction where equilibrium doesn't exist?Why?





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Postby victor » Sun Feb 26, 2006 2:30 pm

If equilibrium doesn't exist then the reaction will run at one direction...means that it not reversible.
example:
1. ATP <=> ADP + Pi

2. ATP ==> ADP + Pi

Which one do you prefer?? of course you don't want eat a plate of ATP as your breakfast aren't you?? :lol:
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Postby 2810712 » Mon Feb 27, 2006 3:36 am

but :roll:
can't irreversible reactions be made to reverse with appropriate free energy supply and catalyst?
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Postby themakes99 » Tue Feb 28, 2006 1:37 am

Does energy involve ATP in all living organisms?
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Postby Poison » Tue Feb 28, 2006 9:52 am

Yes.
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Postby MrMistery » Tue Feb 28, 2006 6:50 pm

@numbers
Of course it can. Most enzymes work this way. What i said wasn't that it is not possible, i was thinking at the problem from an evolution point of view. It is easier to put the reactants in a hidrophobic pocket and let the reaction run for itself rather than help reactants react.

Furthermore, with me reading signal transduction lately, i realised another thing: if you were to use ADP and AMP instead of ATP and ADP the following problem would arise. When you have a signal transduction pathway that uses cAMP and it is turned off, you have to "recycle" all that cAMP. this is done by an enzyme named phosphodiesterase, that turns cAMP into regular AMP. However, this would be a catastory if the cell would be using ADP-AMP. All that generated AMP would act as an alosteical activator for enzymes in cellular respiration, generating energy that, at that point, wasn't needed, therefore creating an unbalance in the cell... So, in order for the cell to use ADP-AMP instead of ATP-ADP it would have to fundamentaly alter a lot of signal transduction pathways...
O course, ATP evolved way before cell comunication, but i am just saying that this path of evolution gave the cell some advantages...
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Postby 2810712 » Thu Mar 02, 2006 10:17 am

thanks, the enzyme thing is quite clearer now...
so the two systems i.e. ADP as currency and the cAMP pathway in its present form cannot exist togather...
BUt still as you have already meantioned the evolutionary sequence matters events also matters... the present compatibility can be used to tell 'why cAMP was use was possible in such a way'...but not 'why ADP wasn't used as energy currency'...

Victor-
If equilibrium doesn't exist then the reaction will run at one direction...means that it not reversible.
example:
1. ATP <=> ADP + Pi

2. ATP ==> ADP + Pi

Which one do you prefer?? of course you don't want eat a plate of ATP as your breakfast aren't you??


BTW, what does ATP taste like :lol:
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