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Definition of Methylation

Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.

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Postby protozoan » Sat Mar 12, 2005 8:21 pm

Forget it... stupid question.
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Postby Poison » Sat Mar 12, 2005 10:42 pm

I don't know if you are still interested in the answer, if yes have a look at the links.
In fact, Inuyasha has already given some info at the beginning but here is a more detailed one:

http://dnamethsoc.server101.com/WhatisD ... lation.htm

This is an example of methylation:

http://www.fragilex.org/html/methylation.htm
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Postby Inuyasha » Sun Mar 13, 2005 1:25 am

hmm. that brigns it back to the question. Where did methlation come from. I don't think our celluar organs have methlyayion. Just DNA. So how did that happen.
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Postby Poison » Sun Mar 13, 2005 4:12 pm

Inuyasha wrote:hmm. that brigns it back to the question. Where did methlation come from. I don't think our celluar organs have methlyayion. Just DNA. So how did that happen.


I think I couldn't understand your question, if so can you please explain it a little more? Or you didn't look at the links.
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Postby protozoan » Tue Mar 15, 2005 7:41 pm

Thanks poison, great links, the first i heard about it i thought it is some technological process, now i know how important it is in the living multicellular organisms. But I cannot defend me from another student questions. Have these methylations even unicellular organisms, which must not regulate their gene expressions (in sense like diferentiated cells of multicellular orgs must)? Or they must? And from what ive read and what really interest me to complete these confusing biological puzzles: if cell undergoes mitosis during which its DNA is highly condensated to the chromosomes does it mean that chromosome is actually highly methylated molecule of DNA? hmmmm?
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Postby Inuyasha » Thu Mar 24, 2005 8:13 pm

My bad, accidently wrote the wrong question. I get it. LOL
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Postby 2810712 » Fri Mar 25, 2005 10:34 am

good qs multicellular protozoan,
I think, multicellular organisms need it to facilitate the repair of DNA, every cell that needs to repair its DNA, will tend to have something homo/ana logous to this and i think, most cells will tend to have this. Because there are many ways to have genetic recombination, but this may also be one of those.
I think, the chromosomes are methylated DNAs while chromatin [active DNA] is also methylated, because ,, if it is not, then what's the use of methylation??? Because, whatever the repair is done, i s done in chromatins, and thus ,methylation pattern must not change during chromosome to chromatin change,

DNA methylation is also , used in molec. bio. tech.s, isn't it???

What does the methyl bind to , in DNA ? ? ?
How, does this act- mechanism i mean???

thanks,

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