Answer this !!

[Dr.Stein]

And "crabs" mean cancer?

I already know this joke but I still can't stop laughing everytime I remember

I think I came late to the test, means that I do not necessary to do them eh?

[opuntia]

Since you are too late that means you won't get any marks, right, Sir Victor?

[victor]

Okay..I'll give the late person a makeup test...
which of these virus family that cause dissease named chicken pox??
a. Hepadnaviridae
b. Retroviridae
c. Herpesviridae
d. Poxviridae
e. Adenoviridae

[opuntia]

c is the correct answer!

[victor]

Yo...you're right fella...
and now, for a lil bit hard one..
HIV have a +sense RNA that can act as mRNA for protein translation...but in the replication process, it doesn't do that...explain why and describe the pathway it use..

[opuntia]

That's too tough for me...coz i haven't studied that yet, so i give up for now but will come up with the answer when i learn them

PS: has it got anything to with the virus having reverse transcriptase?

[victor]

actually you can answer it...just see the picture of HIV in my signature...it helps you a lot...
a clue: +sense RNA virus that use it's RNA as mRNA can be classifid into ssRNA (single stranded RNA, or in other words, haploid RNA)...happy answering..

[Nite]

ds DNA is formed from the +RNA by reverse transcriptase. The ds DNA is then incorporated into the host chromosomal DNA and the virus enters lysogeny cycle.

It's a characteristic of retrovirus as u mention before?

why it does so? guess it does that so that it can be incorporated into the host DNA?

hehe. i just had a lecture about HIV today .
i m a newbie in virology

btw, wad does GAG and GP in the HIV diagram stand for?

[victor]

Yup, that's the "common" characteristics of retroviruses....why I call it common??because there're three subfamilies of retroviruses: Oncovirus, Lentivirus and .....virus..(argh, I forgot the name)..poor me..
Why it does so? because according to Baltimore virus' classification, retroviridae is classified into dsRNA with DNA intermediate (reverse transcriptase) which has a diploid RNA attached to reverse transcriptase enzyme for each of them....and also, in order to do capsid "uncoating", they have to do so..
gag is a code for virion's protein construction.
gp = glycoprotein... so, gp120 = glycoprotein code 120...
easy isn't it..
don't say like that Nite, because I'm also a newbie in Virology and now, I'm learning for the next virus which is Herpesvirus..

[victor]

And now, for the next question..
I've just read about EBV or in other words every body's virus.. (it's real name).
Now, if EBV crates Lymphoblastoma on B-cell and affecting of excesses IgM antibody secretion, then why it's said than EBV is harmful for us?? more antibody is better isn't it??:lol:

[Dr.Stein]

Naah. The excessive IgM and IgG is because of the excessive VCA/EBV/EBNA. You know the immune response... If you want to get those immunoglobulins for more, ok ok I will inject you with more EBV, agree? Maybe you want to experience how is the feeling of suffering mononucleosis, Burkitt's lymphoma and nasopharyngeal carcinoma. Come to me my dear, I still have some vials of EBV mwahahahaa

[victor]

the answer is excessive on IgM can cause erythrocyte aglutination..hahaha..and beside, the infected B-cell secretes an IL-10 like protein that cause inhibition of IFN-gamma secreation in T-cell and NK-cell..