Login

Join for Free!
112080 members


RNA VS ENZYMES

Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.

Moderator: BioTeam

Do U believe the RNA world hypothesis ?

Poll ended at Mon Feb 21, 2005 8:18 am

ya
3
100%
no
0
No votes
 
Total votes : 3

RNA VS ENZYMES

Postby 2810712 » Sat Jan 22, 2005 8:18 am

I think, many of us R familier with the hypothesis of RNA world . I was wondering if we create an RNA-catalyst , because if we get such a thing it will certainly prooove the hypothesis. I M very interested in this field & request U all to recomend me useful sites regarding this.
THANKS!!!!
2810712
King Cobra
King Cobra
 
Posts: 697
Joined: Thu Jan 20, 2005 12:19 pm

Re: RNA VS ENZYMES

Postby thank.darwin » Thu Feb 10, 2005 1:29 am

2810713 wrote:. I was wondering if we create an RNA-catalyst , because if we get such a thing it will certainly prooove the hypothesis.


What do you mean - If we create an RNA- catalyst - Are you asking whether or not they can be created? or if they exists?
No amount of experimentation can ever prove me right; a single experiment can prove me wrong.
-Albert Einstein
User avatar
thank.darwin
Inland Taipan
Inland Taipan
 
Posts: 347
Joined: Thu Jan 27, 2005 7:39 pm
Location: Vancouver, Canada

Postby canalon » Sun Feb 13, 2005 5:44 pm

RNA-catalyst? You mean self replicating RNA? RNA with enzymatic abilities?
I don't know for the first, but for the latter, I suggest you look for Ribozymes. They are catalytic RNA, and are indeed a strong foundation for the RNA world hypothesis.
User avatar
canalon
Inland Taipan
Inland Taipan
 
Posts: 3909
Joined: Thu Feb 03, 2005 2:46 pm
Location: Canada


Postby thank.darwin » Mon Feb 14, 2005 9:40 pm

Canalon wrote: RNA with enzymatic abilities?


There are RNA enzymes out there you know...
No amount of experimentation can ever prove me right; a single experiment can prove me wrong.
-Albert Einstein
User avatar
thank.darwin
Inland Taipan
Inland Taipan
 
Posts: 347
Joined: Thu Jan 27, 2005 7:39 pm
Location: Vancouver, Canada

Re: RNA VS ENZYMES

Postby prometheusmax » Sun Feb 27, 2005 1:01 am

2810713 wrote:I think, many of us R familier with the hypothesis of RNA world . I was wondering if we create an RNA-catalyst , because if we get such a thing it will certainly prooove the hypothesis. I M very interested in this field & request U all to recomend me useful sites regarding this.
THANKS!!!!


This article in interesting and relevant to your question:
This article from Virology Journal (http://www.virologyj.com/home) might be of interest to the readership as it (among other things) describes a mechanism that enables protein information to modify RNA information, and is a mechanism of Larmarkian inheritance. The author makes it clear that it remains consistent with Darwinian selection. It also suggest potential weaknesses in viral replication that might be exploited.
Hepatitis C (HCV), hepatitis B (HBV), the human immunodeficiency viruses (HIV), and other viruses that replicate via RNA intermediaries, cause an enormous burden of disease and premature death worldwide. These viruses circulate within infected hosts as vast populations of closely related, but genetically diverse, molecules known as "quasispecies". The mechanism(s) by which this extreme genetic and antigenic diversity is stably maintained are unclear, but are fundamental to understanding viral persistence and pathobiology. The persistence of HCV, an RNA virus, is especially problematic and HCV stability, maintained despite rapid genomic mutation, is highly paradoxical. This paper presents the hypothesis, and evidence, that viruses capable of persistent infection autoregulate replication and the likely mechanism mediating autoregulation--Replicative Homeostasis--is described. Replicative homeostasis causes formation of stable, but highly reactive, equilibria that drive quasispecies expansion and generates escape mutation. Replicative homeostasis explains both viral kinetics and the enigma of RNA quasispecies stability and provides a rational, mechanistic basis for all observed viral behaviours and host responses. More importantly, this paradigm has specific therapeutic implication and defines, precisely, new approaches to antiviral therapy. Replicative homeostasis may also modulate cellular gene expression.
prometheusmax
Garter
Garter
 
Posts: 6
Joined: Sun Feb 27, 2005 12:40 am

Postby mith » Sun Feb 27, 2005 2:13 am

Ummm why are you posting the same article 4 times to different questions?
Living one day at a time;
Enjoying one moment at a time;
Accepting hardships as the pathway to peace;
~Niebuhr
User avatar
mith
Inland Taipan
Inland Taipan
 
Posts: 5345
Joined: Thu Jan 20, 2005 8:14 pm
Location: Nashville, TN

Postby robotics » Sun Feb 27, 2005 5:38 am

I'd say at least 99 percent of all enzymes are proteins, but you're right, there are some RNA catalysts.

RNA-catalyst? You mean self replicating RNA? RNA with enzymatic abilities?
I don't know for the first, but for the latter, I suggest you look for Ribozymes. They are catalytic RNA, and are indeed a strong foundation for the RNA world hypothesis.


Exactly what he said :) Look for something like Ribozymes, they have enzyme-like properties (can serve as a catalyst, lowering activation energies of reactions, etc) but are in fact RNA.

The RNA hypothesis certainly explains a lot of things, and also suggests a plausible explanation for how DNA came to arise. I can see why you're interested in that field :)
robotics
Garter
Garter
 
Posts: 14
Joined: Sat Feb 26, 2005 10:04 am

Yeah!

Postby 2810712 » Fri Mar 04, 2005 10:02 am

R ribozymes same as enzymes [ in properties except building blocks ] ?
The RNA hypothesis certainly explains a lot of things, and also suggests a plausible explanation for how DNA came to arise. I can see why you're interested in that field
- intelligent :D

hrushikesh
2810712
King Cobra
King Cobra
 
Posts: 697
Joined: Thu Jan 20, 2005 12:19 pm


Return to Molecular Biology

Who is online

Users browsing this forum: No registered users and 1 guest

cron