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How did endosymbionts coordinate replication?

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How did endosymbionts coordinate replication?

Postby lizzymichigan » Tue Dec 18, 2012 12:06 am

If you could link me to a scholarly article that describes how after endosymbiosis, the bacterial cell and it's eukaryotic host coordinated replication (or if you can explain it to me yourself) I would be really grateful. Originally, they replicated separately, so I'm not sure how they stayed together through generations. Was there some sort of chemical messenger that the mitochondria of a cell received to know it was time to replicate? I don't know. Science help.
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Re: How did endosymbionts coordinate replication?

Postby jonmoulton » Fri Dec 21, 2012 4:17 pm

It's an interesting question.

I found this on a quick search. It describes a special case, but at least addresses the question.

http://www.plosone.org/article/info%3Ad ... ne.0008458
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Postby JackBean » Fri Dec 21, 2012 10:38 pm

Mitochondria replicate pretty much independently, so I don't think there was any synchronisation.
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.
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Re: How did endosymbionts coordinate replication?

Postby jonmoulton » Mon Dec 24, 2012 4:24 pm

There must be some synchronization cues; otherwise many cells would end up with over- or under-optimal numbers of mitochondria. Since many of the critical proteins in a mitochondrian are nuclear-encoded, the proliferation of the mitochondria can be limited by the availability of the nuclear-encoded gene products. It would be interesting if there are faster linkages, such as signaling cascades, the trigger mitochondrial replication checkpoints. I'm speculating; has anyone looked into the literature on this?
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Postby JackBean » Tue Dec 25, 2012 5:11 pm

That's good point. But I still don't think the regulation is very tight.
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Re: How did endosymbionts coordinate replication?

Postby kk » Tue Feb 26, 2013 8:29 am

Just a question about mtDNA:

According to the endosymbiontic theory mitochondria were ancient bacteria that survived in an ancient eukaryotic cell and continued to live as part of it as an organelle. So, I suppose, in any eukaryotic cell the mtDNA should be relatively conserved. However, the mutational rate of mtDNA is ten fold higher than that of nuclear DNA. So is the mtDNA sequence conserved among e.g. various mammalian species or the opposite?
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Postby kk » Fri Jun 06, 2014 12:16 pm

Another question about mtDNA: what is the advantage to/role of having multiple copies of the same circular DNA molecule? Isn't that "too much of a dose" of the same given gene? Any mitochondria expert out here?
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Re: How did endosymbionts coordinate replication?

Postby jonmoulton » Wed Jun 11, 2014 2:08 pm

Regarding the regulation of replication of mitochondria, this paper discusses an influence of tumor necrosis factor alpha on mitochondrial replication while exploring the effect of adenosine on that regulatory system.

http://www.plosone.org/article/info%3Ad ... ne.0098459

Kalogeris TJ, Baines C, Korthuis RJ (2014) Adenosine Prevents TNFα-Induced Decrease in Endothelial Mitochondrial Mass via Activation of eNOS-PGC-1α Regulatory Axis. PLoS ONE 9(6): e98459. doi:10.1371/journal.pone.0098459
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Re: How did endosymbionts coordinate replication?

Postby jonmoulton » Wed Jun 11, 2014 10:22 pm

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